Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17564502
TITLE
Age at first sexual intercourse and teenage pregnancy in Australian female twins.
ABSTRACT
Girls who report first sexual intercourse during their early teen years have much higher rates of teenage pregnancy and childbearing than girls who delay sexual onset until older adolescence. In this study, we examine genetic and environmental influences on variation in teenage pregnancy and covariation with age at first sexual intercourse in two cohorts of Australian female twins. In the older twin cohort, born 1893-1964, we observe substantial heritable variation in teenage pregnancy that is largely shared with heritable variation in age at first sexual intercourse, with shared environment contributing little to variation in teenage pregnancy. Genetic influences on teenage pregnancy are smaller and nonsignificant in the younger twin cohort, born 1964-1971, where shared environment contributes much more and overlaps entirely with shared environmental variation in age at first intercourse.
DATE PUBLISHED
2007 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2007/06/15 09:00
medline 2007/08/22 09:00
entrez 2007/06/15 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Waldron M Waldron Mary M Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, United States of America. waldronm@psychiatry.wustl.edu
Heath AC Heath Andrew C AC
Turkheimer E Turkheimer Eric E
Emery R Emery Robert R
Bucholz KK Bucholz Kathleen K KK
Madden PA Madden Pamela A F PA
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 3
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2007
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07720 NIAAA NIH HHS United States
AA10242 NIAAA NIH HHS United States
AA1998 NIAAA NIH HHS United States
T32AA0750 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Australia
Cohort Studies
Coitus
Environment
Female
Humans
Middle Aged
Models, Statistical
Pregnancy
Pregnancy in Adolescence statistics & numerical data
Twins, Dizygotic psychology
Twins, Monozygotic psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's