Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17559308
TITLE
Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci.
ABSTRACT
Twin cohorts provide a unique advantage for investigations of the role of genetics and environment in the etiology of variation in common complex traits by reducing the variance due to environment, age, and cohort differences. The GenomEUtwin (http://www.genomeutwin.org) consortium consists of eight twin cohorts (Australian, Danish, Dutch, Finnish, Italian, Norwegian, Swedish, and United Kingdom) with the total resource of hundreds of thousands of twin pairs. We performed quantitative trait locus (QTL) analysis of one of the most heritable human complex traits, adult stature (body height) using genome-wide scans performed for 3,817 families (8,450 individuals) derived from twin cohorts from Australia, Denmark, Finland, Netherlands, Sweden, and United Kingdom with an approximate ten-centimorgan microsatellite marker map. The marker maps for different studies differed and they were combined and related to the sequence positions using software developed by us, which is publicly available (https://apps.bioinfo.helsinki.fi/software/cartographer.aspx). Variance component linkage analysis was performed with age, sex, and country of origin as covariates. The covariate adjusted heritability was 81% for stature in the pooled dataset. We found evidence for a major QTL for human stature on 8q21.3 (multipoint logarithm of the odds 3.28), and suggestive evidence for loci on Chromosomes X, 7, and 20. Some evidence of sex heterogeneity was found, however, no obvious female-specific QTLs emerged. Several cohorts contributed to the identified loci, suggesting an evolutionarily old genetic variant having effects on stature in European-based populations. To facilitate the genetic studies of stature we have also set up a website that lists all stature genome scans published and their most significant loci (http://www.genomeutwin.org/stature_gene_map.htm).
DATE PUBLISHED
2007 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2007/02/04
accepted 2007/05/02
aheadofprint 2007/05/02
pubmed 2007/06/15 09:00
medline 2007/08/31 09:00
entrez 2007/06/15 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Perola M Perola Markus M Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland.
Sammalisto S Sammalisto Sampo S
Hiekkalinna T Hiekkalinna Tero T
Martin NG Martin Nick G NG
Visscher PM Visscher Peter M PM
Montgomery GW Montgomery Grant W GW
Benyamin B Benyamin Beben B
Harris JR Harris Jennifer R JR
Boomsma D Boomsma Dorret D
Willemsen G Willemsen Gonneke G
Hottenga JJ Hottenga Jouke-Jan JJ
Christensen K Christensen Kaare K
Kyvik KO Kyvik Kirsten Ohm KO
Sørensen TI Sørensen Thorkild I A TI
Pedersen NL Pedersen Nancy L NL
Magnusson PK Magnusson Patrik K E PK
Spector TD Spector Tim D TD
Widen E Widen Elisabeth E
Silventoinen K Silventoinen Karri K
Kaprio J Kaprio Jaakko J
Palotie A Palotie Aarno A
Peltonen L Peltonen Leena L
GenomEUtwin Project
INVESTIGATORS
JOURNAL
VOLUME: 3
ISSUE: 6
TITLE: PLoS genetics
ISOABBREVIATION: PLoS Genet.
YEAR: 2007
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1553-7404
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS Genet
COUNTRY: United States
ISSNLINKING: 1553-7390
NLMUNIQUEID: 101239074
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Body Height genetics
Cohort Studies genetics
European Continental Ancestry Group genetics
Female genetics
Genetic Linkage genetics
Genome, Human genetics
Humans genetics
Lod Score genetics
Male genetics
Models, Genetic genetics
Models, Statistical genetics
Twins, Dizygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC1892350 NLM
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