|
|
| PMID |
|
|
| TITLE |
|
| Linkage of nicotine dependence and smoking behavior on 10q, 7q and 11p in twins with homogeneous genetic background. |
|
| ABSTRACT |
|
|
|
| The significant worldwide health burden introduced by tobacco smoking highlights the importance of studying the genetic determinants of smoking behavior and the key factor sustaining compulsive smoking, that is, nicotine dependence (ND). We have here addressed the genetic background of smoking in a special study sample of twins, harmonized for early life events and specifically ascertained for smoking from the nationwide twin cohort of the genetically unique population of Finland. The twins and their families were carefully examined for extensive phenotype profiles and a genome-wide scan was performed to identify loci behind the smoking status, ND and the comorbid phenotype of ND and alcohol use in 505 individuals from 153 families. We replicated previous linkage findings on 10q (max logarithm of the odds (LOD) 3.12) for a smoker phenotype, and on 7q and 11p (max LOD 2.50, and 2.25, respectively) for the ND phenotype. The loci linked for ND also showed evidence for linkage for the comorbid phenotype. Our study provides confirmatory evidence for the involvement of these genome regions in the genetic etiology of smoking behavior and ND and for the first time associates drinking and smoking to a shared locus on 10q. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2007/06/05 |
| pubmed |
2007/06/06 09:00 |
| medline |
2008/07/02 09:00 |
| entrez |
2007/06/06 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Loukola A |
|
Loukola |
A |
A |
|
Department of Molecular Medicine, National Public Health Institute, Helsinki, Finland. |
| Broms U |
|
Broms |
U |
U |
|
|
| Maunu H |
|
Maunu |
H |
H |
|
|
| Widén E |
|
Widén |
E |
E |
|
|
| Heikkilä K |
|
Heikkilä |
K |
K |
|
|
| Siivola M |
|
Siivola |
M |
M |
|
|
| Salo A |
|
Salo |
A |
A |
|
|
| Pergadia ML |
|
Pergadia |
M L |
ML |
|
|
| Nyman E |
|
Nyman |
E |
E |
|
|
| Sammalisto S |
|
Sammalisto |
S |
S |
|
|
| Perola M |
|
Perola |
M |
M |
|
|
| Agrawal A |
|
Agrawal |
A |
A |
|
|
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Madden PA |
|
Madden |
P A F |
PA |
|
|
| Peltonen L |
|
Peltonen |
L |
L |
|
|
| Kaprio J |
|
Kaprio |
J |
J |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 8 |
| ISSUE: 3 |
| TITLE: The pharmacogenomics journal |
| ISOABBREVIATION: Pharmacogenomics J. |
| YEAR: 2008 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1473-1150 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Pharmacogenomics J |
| COUNTRY: United States |
| ISSNLINKING: 1470-269X |
| NLMUNIQUEID: 101083949 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| DA019951 |
NIDA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| K08 DA019951 |
NIDA NIH HHS |
United States |
| K08 DA019951-03 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Chromosome Mapping |
|
| Chromosomes, Human, Pair 10 |
|
| Chromosomes, Human, Pair 11 |
|
| Chromosomes, Human, Pair 7 |
|
| Female |
|
| Genetic Linkage |
|
| Genotype |
|
| Humans |
|
| Lod Score |
|
| Male |
|
| Middle Aged |
|
| Phenotype |
|
| Smoking |
genetics |
| Tobacco Use Disorder |
genetics |
| Twins |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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|
