Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
17542849
TITLE
Mapping quantitative trait Loci underlying fitness-related traits in a free-living sheep population.
ABSTRACT
We searched for quantitative trait loci (QTL) underlying fitness-related traits in a free-living pedigree of 588 Soay sheep in which a genetic map using 251 markers with an average spacing of 15 cM had been established previously. Traits examined included birth date and weight, considered both as maternal and offspring traits, foreleg length, hindleg length, and body weight measured on animals in August and jaw length and metacarpal length measured on cleaned skeletal material. In some cases the data were split to consider different age classes separately, yielding a total of 15 traits studied. Genetic and environmental components of phenotypic variance were estimated for each trait and, for those traits showing nonzero heritability (N= 12), a QTL search was conducted by comparing a polygenic model with a model including a putative QTL. Support for a QTL at genome-wide significance was found on chromosome 11 for jaw length; suggestive QTL were found on chromosomes 2 and 5 (for birth date as a trait of the lamb), 8 (birth weight as a trait of the lamb), and 15 (adult hindleg length). We discuss the prospects for refining estimates of QTL position and effect size in the study population, and for QTL searches in free-living pedigrees in general.
DATE PUBLISHED
2007 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2007/06/05 09:00
medline 2007/08/01 09:00
entrez 2007/06/05 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Beraldi D Beraldi Dario D Institute of Evolutionary Biology, School of Biological Sciences, University of Edinburgh, Edinburgh, UK. dario.beraldi@ed.ac.uk
McRae AF McRae Allan F AF
Gratten J Gratten Jacob J
Slate J Slate Jon J
Visscher PM Visscher Peter M PM
Pemberton JM Pemberton Josephine M JM
INVESTIGATORS
JOURNAL
VOLUME: 61
ISSUE: 6
TITLE: Evolution; international journal of organic evolution
ISOABBREVIATION: Evolution
YEAR: 2007
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0014-3820
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Evolution
COUNTRY: United States
ISSNLINKING: 0014-3820
NLMUNIQUEID: 0373224
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Animals
Birth Weight genetics
Body Size genetics
Chromosome Mapping genetics
Genetic Markers genetics
Genetic Variation genetics
Genome genetics
Phenotype genetics
Quantitative Trait Loci genetics
Sheep genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
OTHER ID's