Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17183649
TITLE
Genetic influences on exercise participation in 37,051 twin pairs from seven countries.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
A sedentary lifestyle remains a major threat to health in contemporary societies. To get more insight in the relative contribution of genetic and environmental influences on individual differences in exercise participation, twin samples from seven countries participating in the GenomEUtwin project were used.
METHODOLOGY NlmCategory: METHODS
Self-reported data on leisure time exercise behavior from Australia, Denmark, Finland, Norway, The Netherlands, Sweden and United Kingdom were used to create a comparable index of exercise participation in each country (60 minutes weekly at a minimum intensity of four metabolic equivalents).
PRINCIPAL FINDINGS NlmCategory: RESULTS
Modest geographical variation in exercise participation was revealed in 85,198 subjects, aged 19-40 years. Modeling of monozygotic and dizygotic twin resemblance showed that genetic effects play an important role in explaining individual differences in exercise participation in each country. Shared environmental effects played no role except for Norwegian males. Heritability of exercise participation in males and females was similar and ranged from 48% to 71% (excluding Norwegian males).
CONCLUSIONS NlmCategory: CONCLUSIONS
Genetic variation is important in individual exercise behavior and may involve genes influencing the acute mood effects of exercise, high exercise ability, high weight loss ability, and personality. This collaborative study suggests that attempts to find genes influencing exercise participation can pool exercise data across multiple countries and different instruments.
DATE PUBLISHED
2006
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2006/09/13
accepted 2006/09/21
aheadofprint 2006/12/20
pubmed 2006/12/22 09:00
medline 2006/12/22 09:01
entrez 2006/12/22 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Stubbe JH Stubbe Janine H JH Department of Biological Psychology, Vrije Universiteit, Amsterdam, Netherlands. jh.stubbe@psy.vu.nl
Boomsma DI Boomsma Dorret I DI
Vink JM Vink Jacqueline M JM
Cornes BK Cornes Belinda K BK
Martin NG Martin Nicholas G NG
Skytthe A Skytthe Axel A
Kyvik KO Kyvik Kirsten O KO
Rose RJ Rose Richard J RJ
Kujala UM Kujala Urho M UM
Kaprio J Kaprio Jaakko J
Harris JR Harris Jennifer R JR
Pedersen NL Pedersen Nancy L NL
Hunkin J Hunkin Janice J
Spector TD Spector Tim D TD
de Geus EJ de Geus Eco J C EJ
INVESTIGATORS
JOURNAL
VOLUME: 1
ISSUE:
TITLE: PloS one
ISOABBREVIATION: PLoS ONE
YEAR: 2006
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1932-6203
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS One
COUNTRY: United States
ISSNLINKING: 1932-6203
NLMUNIQUEID: 101285081
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA013320 NIAAA NIH HHS United States
AA07535 NIAAA NIH HHS United States
AA08315 NIAAA NIH HHS United States
AA12502 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
Wellcome Trust United Kingdom
GENERAL NOTE
GENERALNOTE: Original DateCompleted: 20070801
OWNER: NLM
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Behavior
Europe
Exercise
Female
Genetics, Behavioral
Humans
Life Style
Male
Models, Genetic
Patient Participation
Registries
Twins, Dizygotic psychology
Twins, Monozygotic psychology
Young Adult psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC1762341 NLM
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Last Modified: Oct 15 2007