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| PMID |
|
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| TITLE |
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| Replication of reported linkages for dyslexia and spelling and suggestive evidence for novel regions on chromosomes 4 and 17. |
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| ABSTRACT |
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| We report the first genome-wide linkage analysis for reading and spelling in a sample of 403 families of twins, aged between 12 and 25 years taken from the normal population and unselected for reading ability. These traits showed heritabilities of 0.52-0.73, and support for linkage exceeded replication levels (lod > 1.44) of seven of the 11 linkages reported in dyslexic samples, namely: 2q22.3, 3p12-q13, 6q11.2, 7q32, 15q21.1, 18p21, and Xq27.3. For five of these (2q22.3, 6q11.2, 7q32, 18p21, and Xq27), this study provides the first independent replication. 1p34-36 and 2p15-16 received some support, with lods of 1.2 and 0.83, respectively, whereas two regions received little support (6p23-21.3 and 11p15.5). This study also identified two novel linkages at 4p15.33-16.1 and 17p13.3, which received suggestive support (max. lod 2.08 and 1.99, respectively). |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2006/11/22 |
| pubmed |
2006/11/23 09:00 |
| medline |
2007/03/17 09:00 |
| entrez |
2006/11/23 09:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Bates TC |
|
Bates |
Timothy C |
TC |
|
Department of Psychology, University of Edinburgh, Edinburgh, UK. tim.bates@ed.ac.uk |
| Luciano M |
|
Luciano |
Michelle |
M |
|
|
| Castles A |
|
Castles |
Anne |
A |
|
|
| Coltheart M |
|
Coltheart |
Max |
M |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 15 |
| ISSUE: 2 |
| TITLE: European journal of human genetics : EJHG |
| ISOABBREVIATION: Eur. J. Hum. Genet. |
| YEAR: 2007 |
| MONTH: Feb |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1018-4813 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Eur J Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1018-4813 |
| NLMUNIQUEID: 9302235 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| N01-HG-65403 |
NHGRI NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Chromosome Mapping |
|
| Chromosomes, Human, Pair 17 |
genetics |
| Chromosomes, Human, Pair 4 |
genetics |
| DNA Replication |
genetics |
| Dyslexia |
genetics |
| Genetic Linkage |
genetics |
| Genome, Human |
genetics |
| Humans |
genetics |
| Reading |
genetics |
| Siblings |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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