Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
17065173
TITLE
Prevalence of premature ovarian failure in monozygotic and dizygotic twins.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Premature ovarian failure (POF) before 40 years of age from natural causes affects approximately 1% of adult women, with minor variations between ethnic groups. A recent case of ovarian transplantation between young monozygotic (MZ) twins in which one had undergone unexplained POF at 14 years has prompted a study of the prevalence of POF.
METHODS NlmCategory: METHODS
Menopausal ages of 832 Australian and UK female twin-pairs were extracted from volunteer national twin registry databases containing medical, reproductive and lifestyle data surveyed by mail questionnaire. Surgical menopause was an exclusion criterion.
RESULTS NlmCategory: RESULTS
The prevalence of POF in both MZ and dizygotic (DZ) twins was similar in both registries and 3- to 5-fold greater than the general population at age thresholds 40 and 45 years. No specific factors were found to account for the higher risk of early menopause. Some twins of both zygosities were highly discordant for menopausal age (>or=10 years). Nevertheless, there was significant intra-twin dependence, especially for MZ twins, and the average age difference at last menses was greater in DZ twin-pairs.
CONCLUSION NlmCategory: CONCLUSIONS
Both MZ and DZ twins are at higher risk of POF. Despite some striking differences within MZ twin-pairs, menopausal ages were more concordant than for DZ twin-pairs, confirming that the timing of menopause has a heritable component.
DATE PUBLISHED
2007 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2006/10/25
pubmed 2006/10/27 09:00
medline 2007/03/17 09:00
entrez 2006/10/27 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Gosden RG Gosden R G RG Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, New York, NY 10021, USA. rgg2004@med.cornell.edu
Treloar SA Treloar S A SA
Martin NG Martin N G NG
Cherkas LF Cherkas L F LF
Spector TD Spector T D TD
Faddy MJ Faddy M J MJ
Silber SJ Silber S J SJ
INVESTIGATORS
JOURNAL
VOLUME: 22
ISSUE: 2
TITLE: Human reproduction (Oxford, England)
ISOABBREVIATION: Hum. Reprod.
YEAR: 2007
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0268-1161
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Hum Reprod
COUNTRY: England
ISSNLINKING: 0268-1161
NLMUNIQUEID: 8701199
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Australia epidemiology
Diseases in Twins epidemiology
Female epidemiology
Great Britain epidemiology
Humans epidemiology
Menopause epidemiology
Middle Aged epidemiology
Prevalence epidemiology
Primary Ovarian Insufficiency epidemiology
Twins, Dizygotic epidemiology
Twins, Monozygotic epidemiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's