Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16930384
TITLE
Genetic and environmental influences on extreme personality dispositions in adolescent female twins.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
The objective was to determine whether the pattern of environmental and genetic influences on deviant personality scores differs from that observed for the normative range of personality, comparing results in adolescent and adult female twins.
METHODS NlmCategory: METHODS
A sample of 2,796 female adolescent twins ascertained from birth records provided Junior Eysenck Personality Questionnaire data. The average age of the sample was 17.0 years (S.D. 2.3). Genetic analyses of continuous and extreme personality scores were conducted. Results were compared for 3,178 adult female twins.
RESULTS NlmCategory: RESULTS
Genetic analysis of continuous traits in adolescent female twins were similar to findings in adult female twins, with genetic influences accounting for between 37% and 44% of the variance in Extraversion (Ex), Neuroticism (N), and Social Non-Conformity (SNC), with significant evidence of shared environmental influences (19%) found only for SNC in the adult female twins. Analyses of extreme personality characteristics, defined categorically, in the adolescent data and replicated in the adult female data, yielded estimates for high N and high SNC that deviated substantially (p < .05) from those obtained in the continuous trait analyses, and provided suggestive evidence that shared family environment may play a more important role in determining personality deviance than has been previously found when personality is viewed continuously. However, multiple-threshold models that assumed the same genetic and environmental determinants of both normative range variation and extreme scores gave acceptable fits for each personality dimension.
CONCLUSIONS NlmCategory: CONCLUSIONS
The hypothesis of differences in genetic or environmental factors responsible for N and SNC among female twins with scores in the extreme versus normative ranges was partially supported, but not for Ex.
DATE PUBLISHED
2006 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2006/08/26 09:00
medline 2006/12/29 09:00
entrez 2006/08/26 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Pergadia ML Pergadia Michele L ML Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA. michelep@matlock.wustl.edu
Madden PA Madden Pamela A F PA
Lessov CN Lessov Christina N CN
Todorov AA Todorov Alexandre A AA
Bucholz KK Bucholz Kathleen K KK
Martin NG Martin Nicholas G NG
Heath AC Heath Andrew C AC
INVESTIGATORS
JOURNAL
VOLUME: 47
ISSUE: 9
TITLE: Journal of child psychology and psychiatry, and allied disciplines
ISOABBREVIATION: J Child Psychol Psychiatry
YEAR: 2006
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0021-9630
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: J Child Psychol Psychiatry
COUNTRY: England
ISSNLINKING: 0021-9630
NLMUNIQUEID: 0375361
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07580 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA09022 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA12232 NIAAA NIH HHS United States
AA12640 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
DA 14363 NIDA NIH HHS United States
DA 14632 NIDA NIH HHS United States
DA12540 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Environment
Female
Follow-Up Studies
Humans
Personality Disorders psychology
Questionnaires psychology
Twins psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's