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| PMID |
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| TITLE |
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| Subtypes of illicit drug users: a latent class analysis of data from an Australian twin sample. |
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| ABSTRACT |
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| This article applies methods of latent class analysis (LCA) to data on lifetime illicit drug use in order to determine whether qualitatively distinct classes of illicit drug users can be identified. Self-report data on lifetime illicit drug use (cannabis, stimulants, hallucinogens, sedatives, inhalants, cocaine, opioids and solvents) collected from a sample of 6265 Australian twins (average age 30 years) were analyzed using LCA. Rates of childhood sexual and physical abuse, lifetime alcohol and tobacco dependence, symptoms of illicit drug abuse/dependence and psychiatric comorbidity were compared across classes using multinomial logistic regression. LCA identified a 5-class model: Class 1 (68.5%) had low risks of the use of all drugs except cannabis; Class 2 (17.8%) had moderate risks of the use of all drugs; Class 3 (6.6%) had high rates of cocaine, other stimulant and hallucinogen use but lower risks for the use of sedatives or opioids. Conversely, Class 4 (3.0%) had relatively low risks of cocaine, other stimulant or hallucinogen use but high rates of sedative and opioid use. Finally, Class 5 (4.2%) had uniformly high probabilities for the use of all drugs. Rates of psychiatric comorbidity were highest in the polydrug class although the sedative/opioid class had elevated rates of depression/suicidal behaviors and exposure to childhood abuse. Aggregation of population-level data may obscure important subgroup differences in patterns of illicit drug use and psychiatric comorbidity. Further exploration of a 'self-medicating' subgroup is needed. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2006/08/11 09:00 |
| medline |
2006/10/13 09:00 |
| entrez |
2006/08/11 09:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, United States of America. mlynskey@wustl.edu |
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
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| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
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| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
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| Madden PA |
|
Madden |
Pamela A F |
PA |
|
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| Todorov AA |
|
Todorov |
Alexandre A |
AA |
|
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| Grant JD |
|
Grant |
Julia D |
JD |
|
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| Martin NG |
|
Martin |
Nicholas G |
NG |
|
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| Heath AC |
|
Heath |
Andrew C |
AC |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 9 |
| ISSUE: 4 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2006 |
| MONTH: Aug |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Research Support, N.I.H., Extramural |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10248 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| DA18267 |
NIDA NIH HHS |
United States |
| DA18660 |
NIDA NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Australia |
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| Child |
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| Child Abuse, Sexual |
psychology |
| Female |
psychology |
| Humans |
psychology |
| Male |
psychology |
| Risk Factors |
psychology |
| Substance-Related Disorders |
psychology |
| Twin Studies as Topic |
psychology |
| Twins |
psychology |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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