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PMID
16868121
TITLE
Development of a linkage map and mapping of phenotypic polymorphisms in a free-living population of Soay sheep (Ovis aries).
ABSTRACT
An understanding of the determinants of trait variation and the selective forces acting on it in natural populations would give insights into the process of evolution. The combination of long-term studies of individuals living in the wild and better genomic resources for nonmodel organisms makes achieving this goal feasible. This article reports the development of a complete linkage map in a pedigree of free-living Soay sheep on St. Kilda and its application to mapping the loci responsible for three morphological polymorphisms for which the maintenance of variation demands explanation. The map was derived from 251 microsatellite and four allozyme markers and covers 3350 cM (approximately 90% of the sheep genome) at approximately 15-cM intervals. Marker order was consistent with the published sheep map with the exception of one region on chromosome 1 and one on chromosome 12. Coat color maps to chromosome 2 where a strong candidate gene, tyrosinase-related protein 1 (TYRP1), has also been mapped. Coat pattern maps to chromosome 13, close to the candidate locus Agouti. Horn type maps to chromosome 10, a location similar to that previously identified in domestic sheep. These findings represent an advance in the dissection of the genetic diversity in the wild and provide the foundation for QTL analyses in the study population.
DATE PUBLISHED
2006 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2006/07/27 09:00
medline 2006/12/09 09:00
entrez 2006/07/27 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Beraldi D Beraldi Dario D Institute of Evolutionary Biology, University of Edinburgh, UK. dario.beraldi@ed.ac.uk
McRae AF McRae Allan F AF
Gratten J Gratten Jacob J
Slate J Slate Jon J
Visscher PM Visscher Peter M PM
Pemberton JM Pemberton Josephine M JM
INVESTIGATORS
JOURNAL
VOLUME: 173
ISSUE: 3
TITLE: Genetics
ISOABBREVIATION: Genetics
YEAR: 2006
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0016-6731
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genetics
COUNTRY: United States
ISSNLINKING: 0016-6731
NLMUNIQUEID: 0374636
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Animals
Chromosome Mapping
Female
Genetic Linkage
Genetic Markers
Male
Microsatellite Repeats
Phenotype
Polymorphism, Genetic
Quantitative Trait Loci
Sheep, Domestic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
OTHER ID's
OTHERID SOURCE
PMC1526682 NLM
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