|
|
| PMID |
|
|
| TITLE |
|
| Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| This study examined the relationships between self-reported childhood sexual abuse (CSA) and drug-related outcomes in an Australian twin panel. |
| METHOD |
NlmCategory: METHODS |
| A semi-structured psychiatric interview was conducted in 1996-2000 by telephone with young adult Australian twins (mean age 29.9 years). Data reported here are from 6050 twins who responded to both CSA and drug-related items. |
| RESULTS |
NlmCategory: RESULTS |
| A history of CSA was associated with significant risk for subsequently occurring regular smoking and use of each illicit drug class. Further CSA-associated risk was found among regular users, for nicotine and alcohol dependence, and among illicit drug users, for abuse/dependence of most drug classes. In same-sex discordant pairs, significant risk for regular smoking and illicit drug use was found in twins with a history of CSA compared to their non-abused co-twins. Similar analyses for abuse/dependence found significant risk for opioids, any illicit drug, and any non-cannabis illicit drug. CSA was associated with significantly earlier drug use. Despite the association of CSA with risk for early-onset cannabis use and regular smoking, risks for illicit drug outcomes associated with CSA and with either form of early-onset use combine in near-additive fashion. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| CSA is associated with risk for subsequently occurring regular smoking and illicit drug use and abuse/dependence. Risks for drug use are mildly attenuated with control for familial contributions; similar risks for abuse/dependence remain significant for opioids and for illicit drugs combined across classes. Although we found evidence of earlier onset drug use with CSA, risks associated with CSA and with early-onset use combine in a largely additive manner. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| aheadofprint |
2006/07/20 |
| pubmed |
2006/07/21 09:00 |
| medline |
2007/01/25 09:00 |
| entrez |
2006/07/21 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA. nelsone@wustl.edu |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
|
| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 36 |
| ISSUE: 10 |
| TITLE: Psychological medicine |
| ISOABBREVIATION: Psychol Med |
| YEAR: 2006 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0033-2917 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Psychol Med |
| COUNTRY: England |
| ISSNLINKING: 0033-2917 |
| NLMUNIQUEID: 1254142 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13446 |
NIAAA NIH HHS |
United States |
| DA17305 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Australia |
epidemiology |
| Child |
epidemiology |
| Child Abuse, Sexual |
statistics & numerical data |
| Female |
statistics & numerical data |
| Humans |
statistics & numerical data |
| Incidence |
statistics & numerical data |
| Male |
statistics & numerical data |
| Prevalence |
statistics & numerical data |
| Questionnaires |
statistics & numerical data |
| Risk Factors |
statistics & numerical data |
| Smoking |
epidemiology |
| Street Drugs |
epidemiology |
| Substance-Related Disorders |
epidemiology |
| Twins |
epidemiology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Street Drugs |
|
| OTHER ID's |
|
|
|
