Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16840847
TITLE
A transdiagnostic approach to understanding eating disorders.
ABSTRACT
Categorical models dominate the eating disorder field, but the tandem use of categorical and dimensional models has been proposed. A transdiagnostic dimensional model, number of lifetime eating disorder behaviors (LEDB), was examined with respect to (1) its relationship to a variety of indicators of the individual's functioning, (2) the degree to which it was influenced by genetic and environmental risk factors, and (3) exposure to specific environmental risk factors. Data from self-report and interview from 1002 female twins (mean age = 34.91 years, SD = 2.09) were examined. While 15.4% women met criteria for a lifetime eating disorder, 29% had at least one LEDB. The dimensional measure provided an indicator of associated functioning, and was influenced primarily by the nonshared environment. The number of LEDB was associated with the degree of impaired functioning. This impairment was associated with conflict between parents and criticism from parents when growing up.
DATE PUBLISHED
2006 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2006/07/15 09:00
medline 2006/08/10 09:00
entrez 2006/07/15 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wade TD Wade Tracey D TD School of Psychology, Flinders University, Adelaide, South Australia, Australia.
Bergin JL Bergin Jacqueline L JL
Martin NG Martin Nicholas G NG
Gillespie NA Gillespie Nathan A NA
Fairburn CG Fairburn Christopher G CG
INVESTIGATORS
JOURNAL
VOLUME: 194
ISSUE: 7
TITLE: The Journal of nervous and mental disease
ISOABBREVIATION: J. Nerv. Ment. Dis.
YEAR: 2006
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0022-3018
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: J Nerv Ment Dis
COUNTRY: United States
ISSNLINKING: 0022-3018
NLMUNIQUEID: 0375402
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
046386 Wellcome Trust United Kingdom
046386 Wellcome Trust United Kingdom
079113 Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Anorexia Nervosa genetics
Australia epidemiology
Bulimia Nervosa genetics
Conflict (Psychology) genetics
Diseases in Twins genetics
Eating Disorders genetics
Female genetics
Humans genetics
Interviews as Topic genetics
Logistic Models genetics
Models, Genetic genetics
Models, Psychological genetics
Parent-Child Relations genetics
Personality Assessment statistics & numerical data
Personality Inventory statistics & numerical data
Psychiatric Status Rating Scales statistics & numerical data
Risk Factors statistics & numerical data
Social Environment statistics & numerical data
Twins, Dizygotic statistics & numerical data
Twins, Monozygotic statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's