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PMID |
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TITLE |
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Genome-wide linkage scan for loci influencing plasma triglycerides. |
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ABSTRACT |
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BACKGROUND |
NlmCategory: BACKGROUND |
Plasma triglyceride concentration is known to be a significant risk factor for cardiovascular disease (CVD). Previous studies have found that the level of triglycerides is strongly influenced by genetic factors. |
METHODS |
NlmCategory: METHODS |
To identify quantitative trait loci influencing triglycerides, we conducted a genome-wide linkage scan on data from 485 Australian adult dizygotic twin pairs. Prior to linkage analysis, triglyceride values were adjusted for the effects of covariates including age, sex, time since last meal, time of blood collection (CT) and time to plasma separation. |
RESULTS |
NlmCategory: RESULTS |
The heritability estimate for ln(triglyceride) adjusted for all above fixed effects was 0.49. The highest multipoint LOD score observed was 2.94 (genome-wide p=0.049) on chromosome 7 (at 65 cM). This 7p region contains several candidate genes. Two other regions with suggestive multipoint LOD scores were also identified on chromosome 4 (LOD score=2.26 at 62 cM) and chromosome X (LOD score=2.01 at 81 cM). |
CONCLUSIONS |
NlmCategory: CONCLUSIONS |
The linkage peaks found represent newly identified regions for more detailed study, in particular the significant linkage observed on chromosome 7p13. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2006/03/01 |
revised |
2006/05/26 |
accepted |
2006/05/26 |
aheadofprint |
2006/06/03 |
pubmed |
2006/07/11 09:00 |
medline |
2007/03/17 09:00 |
entrez |
2006/07/11 09:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Middelberg RP |
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Middelberg |
Rita P |
RP |
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Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Queensland, Australia. ritaM@qimr.edu.au |
Martin NG |
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Martin |
Nicholas G |
NG |
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Montgomery GW |
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Montgomery |
Grant W |
GW |
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Whitfield JB |
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Whitfield |
John B |
JB |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 374 |
ISSUE: 1-2 |
TITLE: Clinica chimica acta; international journal of clinical chemistry |
ISOABBREVIATION: Clin. Chim. Acta |
YEAR: 2006 |
MONTH: Dec |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 0009-8981 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Clin Chim Acta |
COUNTRY: Netherlands |
ISSNLINKING: 0009-8981 |
NLMUNIQUEID: 1302422 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
Twin Study |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
AA007535 |
NIAAA NIH HHS |
United States |
AA014041 |
NIAAA NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
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Aged |
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Aged, 80 and over |
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Australia |
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Chromosomes, Human, Pair 7 |
genetics |
Female |
genetics |
Genetic Linkage |
genetics |
Genome, Human |
genetics |
Humans |
genetics |
Lod Score |
genetics |
Male |
genetics |
Middle Aged |
genetics |
Quantitative Trait Loci |
genetics |
Triglycerides |
blood |
Twins, Dizygotic |
blood |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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REGISTRYNUMBER |
NAMEOFSUBSTANCE |
0 |
Triglycerides |
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OTHER ID's |
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