|
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| PMID |
|
|
| TITLE |
|
| Variance decomposition of apolipoproteins and lipids in Danish twins. |
|
| ABSTRACT |
|
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| Twin studies are used extensively to decompose the variance of a trait, mainly to estimate the heritability of the trait. A second purpose of such studies is to estimate to what extent the non-genetic variance is shared or specific to individuals. To a lesser extent the twin studies have been used in bivariate or multivariate analysis to elucidate common genetic factors to two or more traits. |
| METHODS AND RESULTS |
NlmCategory: RESULTS |
| In the present study the variances of traits related to lipid metabolism is decomposed in a relatively large Danish twin population, including bivariate analysis to detect possible common genetic factors of the traits. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| The heritabilities of apolipoprotein B and E, cholesterol, LDL, and high density lipoprotein (HDL) were significant in the general population, although gender-specific levels and significance were detected. Heritabilities of apolipoprotein A1, triglycerides, and very low density protein (VLDL) were only significant when the population was stratified according to gender. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2006/01/03 |
| revised |
2006/04/25 |
| accepted |
2006/04/25 |
| aheadofprint |
2006/05/26 |
| pubmed |
2006/05/30 09:00 |
| medline |
2007/04/11 09:00 |
| entrez |
2006/05/30 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Fenger M |
|
Fenger |
Mogens |
M |
|
Department of Clinical Biochemistry and Molecular Biology, University Hospital of Copenhagen, KBA339, Kettegaard Alle 30, 2650 Hvidovre, Denmark. mogens.fenger@hh.hosp.dk |
| Benyamin B |
|
Benyamin |
Beben |
B |
|
|
| Schousboe K |
|
Schousboe |
Karoline |
K |
|
|
| Sørensen TI |
|
Sørensen |
Thorkild I A |
TI |
|
|
| Kyvik KO |
|
Kyvik |
Kirsten O |
KO |
|
|
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| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 191 |
| ISSUE: 1 |
| TITLE: Atherosclerosis |
| ISOABBREVIATION: Atherosclerosis |
| YEAR: 2007 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0021-9150 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Atherosclerosis |
| COUNTRY: Ireland |
| ISSNLINKING: 0021-9150 |
| NLMUNIQUEID: 0242543 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| ErratumIn |
Atherosclerosis. 2008 Oct;200(2):451 |
|
Benyamin, Beben [added] |
|
| GRANTS |
|
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| GENERAL NOTE |
|
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| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Apolipoproteins |
genetics |
| Cholesterol |
genetics |
| Denmark |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Lipoproteins |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Multivariate Analysis |
genetics |
| Quantitative Trait, Heritable |
genetics |
| Sex Factors |
genetics |
| Triglycerides |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Apolipoproteins |
| 0 |
Lipoproteins |
| 0 |
Triglycerides |
| 97C5T2UQ7J |
Cholesterol |
|
| OTHER ID's |
|
|
|
