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PMID |
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TITLE |
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Heritability and genetic covariation of sensitivity to PROP, SOA, quinine HCl, and caffeine. |
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ABSTRACT |
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The perceived bitterness intensity for bitter solutions of propylthiouracil (PROP), sucrose octa-acetate (SOA), quinine HCl and caffeine were examined in a genetically informative sample of 392 females and 313 males (mean age of 17.8 +/- 3.1 years), including 62 monozygotic and 131 dizygotic twin pairs and 237 sib pairs. Broad-sense heritabilities were estimated at 0.72, 0.28, 0.34, and 0.30 for PROP, SOA, quinine, and caffeine, respectively, for perceived intensity measures. Modeling showed 1) a group factor which explained a large amount of the genetic variation in SOA, quinine, and caffeine (22-28% phenotypic variation), 2) a factor responsible for all the genetic variation in PROP (72% phenotypic variation), which only accounted for 1% and 2% of the phenotypic variation in SOA and caffeine, respectively, and 3) a modest specific genetic factor for quinine (12% phenotypic variation). Unique environmental influences for all four compounds were due to a single factor responsible for 7-22% of phenotypic variation. The results suggest that the perception of PROP and the perception of SOA, quinine, and caffeine are influenced by two distinct sets of genes. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
aheadofprint |
2006/03/09 |
pubmed |
2006/03/11 09:00 |
medline |
2006/08/25 09:00 |
entrez |
2006/03/11 09:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Hansen JL |
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Hansen |
Jonathan L |
JL |
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Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia. Jonathan.Hansen@qimr.edu.au |
Reed DR |
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Reed |
Danielle R |
DR |
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Wright MJ |
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Wright |
Margaret J |
MJ |
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Martin NG |
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Martin |
Nicholas G |
NG |
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Breslin PA |
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Breslin |
Paul A S |
PA |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 31 |
ISSUE: 5 |
TITLE: Chemical senses |
ISOABBREVIATION: Chem. Senses |
YEAR: 2006 |
MONTH: Jun |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 0379-864X |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Chem Senses |
COUNTRY: England |
ISSNLINKING: 0379-864X |
NLMUNIQUEID: 8217190 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
Twin Study |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
DC02995 |
NIDCD NIH HHS |
United States |
DC04698 |
NIDCD NIH HHS |
United States |
R01 DC004698 |
NIDCD NIH HHS |
United States |
R03 DC003509 |
NIDCD NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adolescent |
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Adult |
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Caffeine |
pharmacology |
Child |
pharmacology |
Female |
pharmacology |
Genetic Variation |
pharmacology |
Humans |
pharmacology |
Inheritance Patterns |
pharmacology |
Male |
pharmacology |
Models, Genetic |
pharmacology |
Phenotype |
pharmacology |
Propylthiouracil |
pharmacology |
Quinine |
pharmacology |
Sensitivity and Specificity |
pharmacology |
Siblings |
pharmacology |
Sucrose |
pharmacology |
Taste |
physiology |
Twins, Dizygotic |
physiology |
Twins, Monozygotic |
physiology |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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REGISTRYNUMBER |
NAMEOFSUBSTANCE |
07V591057T |
sucrose octaacetate |
3G6A5W338E |
Caffeine |
57-50-1 |
Sucrose |
721M9407IY |
Propylthiouracil |
A7V27PHC7A |
Quinine |
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OTHER ID's |
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OTHERID |
SOURCE |
NIHMS8856 |
NLM |
PMC1475779 |
NLM |
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