Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16527870
TITLE
Heritability and genetic covariation of sensitivity to PROP, SOA, quinine HCl, and caffeine.
ABSTRACT
The perceived bitterness intensity for bitter solutions of propylthiouracil (PROP), sucrose octa-acetate (SOA), quinine HCl and caffeine were examined in a genetically informative sample of 392 females and 313 males (mean age of 17.8 +/- 3.1 years), including 62 monozygotic and 131 dizygotic twin pairs and 237 sib pairs. Broad-sense heritabilities were estimated at 0.72, 0.28, 0.34, and 0.30 for PROP, SOA, quinine, and caffeine, respectively, for perceived intensity measures. Modeling showed 1) a group factor which explained a large amount of the genetic variation in SOA, quinine, and caffeine (22-28% phenotypic variation), 2) a factor responsible for all the genetic variation in PROP (72% phenotypic variation), which only accounted for 1% and 2% of the phenotypic variation in SOA and caffeine, respectively, and 3) a modest specific genetic factor for quinine (12% phenotypic variation). Unique environmental influences for all four compounds were due to a single factor responsible for 7-22% of phenotypic variation. The results suggest that the perception of PROP and the perception of SOA, quinine, and caffeine are influenced by two distinct sets of genes.
DATE PUBLISHED
2006 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2006/03/09
pubmed 2006/03/11 09:00
medline 2006/08/25 09:00
entrez 2006/03/11 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hansen JL Hansen Jonathan L JL Genetic Epidemiology Group, Queensland Institute of Medical Research, Brisbane, Australia. Jonathan.Hansen@qimr.edu.au
Reed DR Reed Danielle R DR
Wright MJ Wright Margaret J MJ
Martin NG Martin Nicholas G NG
Breslin PA Breslin Paul A S PA
INVESTIGATORS
JOURNAL
VOLUME: 31
ISSUE: 5
TITLE: Chemical senses
ISOABBREVIATION: Chem. Senses
YEAR: 2006
MONTH: Jun
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0379-864X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Chem Senses
COUNTRY: England
ISSNLINKING: 0379-864X
NLMUNIQUEID: 8217190
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
DC02995 NIDCD NIH HHS United States
DC04698 NIDCD NIH HHS United States
R01 DC004698 NIDCD NIH HHS United States
R03 DC003509 NIDCD NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Caffeine pharmacology
Child pharmacology
Female pharmacology
Genetic Variation pharmacology
Humans pharmacology
Inheritance Patterns pharmacology
Male pharmacology
Models, Genetic pharmacology
Phenotype pharmacology
Propylthiouracil pharmacology
Quinine pharmacology
Sensitivity and Specificity pharmacology
Siblings pharmacology
Sucrose pharmacology
Taste physiology
Twins, Dizygotic physiology
Twins, Monozygotic physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
07V591057T sucrose octaacetate
3G6A5W338E Caffeine
57-50-1 Sucrose
721M9407IY Propylthiouracil
A7V27PHC7A Quinine
OTHER ID's
OTHERID SOURCE
NIHMS8856 NLM
PMC1475779 NLM
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