Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16365831
TITLE
A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families.
ABSTRACT
Many twin studies have identified sex differences in the influence of genetic and environmental factors on smoking behaviors. We explore the evidence for sex differences for smoking initiation and cigarette consumption in a sample of Australian twin families, and extend these models to incorporate sex differences in linkage analyses for these traits. We further examine the impact of including or excluding non-smokers in genetic analyses of tobacco consumption. Accounting for sex differences improved linkage results in some instances. We identified one region suggestive of linkage on chromosome 11p12. This locus, as well as another region identified on chromosome 6p12, replicates regions identified in previous studies.
DATE PUBLISHED
2006 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2005/02/06
accepted 2005/08/04
aheadofprint 2005/12/20
pubmed 2005/12/21 09:00
medline 2006/10/06 09:00
entrez 2005/12/21 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Morley KI Morley Katherine I KI Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia. kateM@qimr.edu.au
Medland SE Medland Sarah E SE
Ferreira MA Ferreira Manuel Ar MA
Lynskey MT Lynskey Michael T MT
Montgomery GW Montgomery Grant W GW
Heath AC Heath Andrew C AC
Madden PA Madden Pamela Af PA
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 36
ISSUE: 1
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2006
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
CA75581 NCI NIH HHS United States
DA00272 NIDA NIH HHS United States
DA12540 NIDA NIH HHS United States
DA12854 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Analysis of Variance
Chromosome Mapping
Chromosomes, Human, Pair 11
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Phenotype
Queensland
Questionnaires
Smoking genetics
Tobacco Use Disorder genetics
Twins, Dizygotic genetics
Twins, Monozygotic genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's