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| PMID |
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| TITLE |
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| A comparison of twin birthweight data from Australia, the Netherlands, the United States, Japan, and South Korea: are genetic and environmental variations in birthweight similar in Caucasians and East Asians? |
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| ABSTRACT |
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| Birthweight has implications for physical and mental health in later life. Using data from Caucasian twins collected in Australia, the Netherlands and the United States, and from East Asian twins collected in Japan and South Korea, we compared the total phenotypic, genetic and environmental variances of birthweight between Caucasians and East Asians. Model-fitting analyses yielded four major findings. First, for both males and females, the total phenotypic variances of birthweight were about 45% larger in Caucasians than in East Asians. The larger phenotypic variances were mainly attributable to a greater shared environmental variance of birthweight in Caucasians (ranging from 62% to 67% of variance) than Asians (48% to 53%). Second, the genetic variance of birthweight was equal in Caucasians and East Asians for both males and females, explaining a maximum of 17% of variance. Third, small variations in total phenotypic variances of birthweight within Caucasians and within East Asians were mainly due to differences in nonshared environmental variances. We speculate that maternal effects (both genetic and environmental) explain the large shared environmental variance in birthweight and may account for the differences in phenotypic variance in birthweight between Caucasians and East Asians. Recent molecular findings and specific environmental factors that are subsumed by maternal effects are discussed. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2005/12/16 09:00 |
| medline |
2006/03/15 09:00 |
| entrez |
2005/12/16 09:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hur YM |
|
Hur |
Yoon-Mi |
YM |
|
Seoul National University Hospital, Seoul, South Korea. ymhur@neuroimage.snu.ac.kr |
| Luciano M |
|
Luciano |
Michelle |
M |
|
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| Martin NG |
|
Martin |
Nicholas G |
NG |
|
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| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
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| Iacono WG |
|
Iacono |
William G |
WG |
|
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| McGue M |
|
McGue |
Matt |
M |
|
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| Shin JS |
|
Shin |
Joong Sik |
JS |
|
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| Jun JK |
|
Jun |
Jong Kwan |
JK |
|
|
| Ooki S |
|
Ooki |
Syuichi |
S |
|
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| van Beijsterveldt CE |
|
van Beijsterveldt |
C E M |
CE |
|
|
| Han JY |
|
Han |
Jung Yeol |
JY |
|
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 8 |
| ISSUE: 6 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2005 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| AA09367 |
NIAAA NIH HHS |
United States |
| CA88363 |
NCI NIH HHS |
United States |
| DA05147 |
NIDA NIH HHS |
United States |
| R01 MH58799-03 |
NIMH NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Asian Continental Ancestry Group |
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| Birth Weight |
genetics |
| Environment |
genetics |
| European Continental Ancestry Group |
genetics |
| Female |
genetics |
| Genetic Variation |
genetics |
| Humans |
genetics |
| Infant, Newborn |
genetics |
| Male |
genetics |
| Maternal Exposure |
genetics |
| Phenotype |
genetics |
| Retrospective Studies |
genetics |
| Twins |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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