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| PMID |
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| TITLE |
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| Familial clustering of major depression and anxiety disorders in Australian and Dutch twins and siblings. |
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| ABSTRACT |
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| The aim of this study was to investigate familial influences and their dependence on sex for panic disorder and/or agoraphobia, social phobia, generalized anxiety disorder and major depression. Data from Australian (N = 2287) and Dutch (N = 1185) twins and siblings who were selected for a linkage study and participated in clinical interviews to obtain lifetime Diagnostic and Statistical Manual of Mental Disorders (4th ed.; DSM-IV) diagnoses were used. In a liability model, tetrachoric correlations were estimated in sibling pairs and sex differences between sibling correlations were tested. For each diagnosis, the sibling correlations could be constrained to be equal across the Australian and Dutch samples. With the exception of panic disorder and/or agoraphobia, all sibling correlations were the same for brother, sister and opposite-sex sibling pairs and were around .20. For panic disorder and/or agoraphobia, the correlation was .23 in brother and sister pairs, but absent in opposite-sex sibling pairs. From these results it can be concluded that upper heritability estimates, based on twice the correlations in the sibling pairs, vary between 36% (major depression) and 50% (social phobia). Furthermore, different genetic risk factors appear to contribute to the vulnerability for panic disorder and/or agoraphobia in men and women. No other sex differences were found. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2005/12/16 09:00 |
| medline |
2006/03/15 09:00 |
| entrez |
2005/12/16 09:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Middeldorp CM |
|
Middeldorp |
Christel M |
CM |
|
Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. Cm.middeldorp@psy.vu.nl |
| Birley AJ |
|
Birley |
Andrew J |
AJ |
|
|
| Cath DC |
|
Cath |
Danielle C |
DC |
|
|
| Gillespie NA |
|
Gillespie |
Nathan A |
NA |
|
|
| Willemsen G |
|
Willemsen |
Gonneke |
G |
|
|
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
|
| de Geus EJ |
|
de Geus |
Eco J C |
EJ |
|
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| Andrews JG |
|
Andrews |
J Gavin |
JG |
|
|
| van Dyck R |
|
van Dyck |
Richard |
R |
|
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| Beem AL |
|
Beem |
A Leo |
AL |
|
|
| Sullivan PF |
|
Sullivan |
Patrick F |
PF |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
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| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 8 |
| ISSUE: 6 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2005 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| MH059160 |
NIMH NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
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| Anxiety Disorders |
genetics |
| Australia |
genetics |
| Depressive Disorder, Major |
genetics |
| Female |
genetics |
| Genetic Linkage |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Netherlands |
genetics |
| Risk Factors |
genetics |
| Sex Factors |
genetics |
| Siblings |
genetics |
| Twins |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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