|
PMID |
|
|
TITLE |
|
Evidence of age-dependent genetic influences on plasma total cholesterol. |
|
ABSTRACT |
|
BACKGROUND |
NlmCategory: BACKGROUND |
Causes of variation in cardiovascular risk factors include biological variation within individuals, and more permanent differences between individuals, which are at least partly genetic in origin. We have compared the magnitude of genetic and non-genetic factors within and across occasions through repeated measures of plasma cholesterol in twin subjects, and have also determined how far the same genes affect cholesterol levels at different ages. |
METHODS |
NlmCategory: METHODS |
Data on plasma total cholesterol were extracted for 208 twin pairs who had provided blood on up to six occasions across a period of 17 years. They were aged 18-30 years at the time of first study and 30-47 at the time of the last. Multivariate models of variation due to genetic, shared environmental and unique environmental factors were fitted to the multi-occasion data and the proportions of variation due to these factors were estimated. |
RESULTS |
NlmCategory: RESULTS |
One genetic factor influenced plasma cholesterol on all occasions and a second genetic factor only influenced cholesterol results on the fifth and sixth occasions 10-17 years after the first. Environmental factors did not have significant long-term effects. |
CONCLUSIONS |
NlmCategory: CONCLUSIONS |
We conclude that individuals' long-term mean plasma cholesterol values are strongly genetically determined, but that some of these genes are age-specific in their effects. |
|
DATE PUBLISHED |
|
|
HISTORY |
|
PUBSTATUS |
PUBSTATUSDATE |
pubmed |
2005/08/05 09:00 |
medline |
2006/07/15 09:00 |
entrez |
2005/08/05 09:00 |
|
AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Middelberg R |
|
Middelberg |
Rita |
R |
|
Genetic Epidemiology Unit, Queensland Institute of Medical Research, Brisbane, Australia. |
Heath AC |
|
Heath |
Andrew C |
AC |
|
|
Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
Whitfield JB |
|
Whitfield |
John B |
JB |
|
|
|
INVESTIGATORS |
|
|
JOURNAL |
|
VOLUME: 12 |
ISSUE: 4 |
TITLE: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology |
ISOABBREVIATION: Eur J Cardiovasc Prev Rehabil |
YEAR: 2005 |
MONTH: Aug |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 1741-8267 |
ISSNTYPE: Print |
|
MEDLINE JOURNAL |
|
MEDLINETA: Eur J Cardiovasc Prev Rehabil |
COUNTRY: England |
ISSNLINKING: 1741-8267 |
NLMUNIQUEID: 101192000 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Comparative Study |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, U.S. Gov't, P.H.S. |
|
COMMENTS AND CORRECTIONS |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
AA007535 |
NIAAA NIH HHS |
United States |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Adolescent |
|
Adult |
|
Aging |
blood |
Australia |
epidemiology |
Biological Markers |
blood |
Cholesterol |
genetics |
Evidence-Based Medicine |
genetics |
Female |
genetics |
Genetic Variation |
genetics |
Humans |
genetics |
Male |
genetics |
Multivariate Analysis |
genetics |
Phenotype |
genetics |
Twin Studies as Topic |
genetics |
Twins |
genetics |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
REGISTRYNUMBER |
NAMEOFSUBSTANCE |
0 |
Biological Markers |
97C5T2UQ7J |
Cholesterol |
|
OTHER ID's |
|
|
|