Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
16020786
TITLE
Quantitative trait locus analysis of longitudinal quantitative trait data in complex pedigrees.
ABSTRACT
There is currently considerable interest in genetic analysis of quantitative traits such as blood pressure and body mass index. Despite the fact that these traits change throughout life they are commonly analyzed only at a single time point. The genetic basis of such traits can be better understood by collecting and effectively analyzing longitudinal data. Analyses of these data are complicated by the need to incorporate information from complex pedigree structures and genetic markers. We propose conducting longitudinal quantitative trait locus (QTL) analyses on such data sets by using a flexible random regression estimation technique. The relationship between genetic effects at different ages is efficiently modeled using covariance functions (CFs). Using simulated data we show that the change in genetic effects over time can be well characterized using CFs and that including parameters to model the change in effect with age can provide substantial increases in power to detect QTL compared with repeated measure or univariate techniques. The asymptotic distributions of the methods used are investigated and methods for overcoming the practical difficulties in fitting CFs are discussed. The CF-based techniques should allow efficient multivariate analyses of many data sets in human and natural population genetics.
DATE PUBLISHED
2005 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2005/07/14
pubmed 2005/07/16 09:00
medline 2006/03/01 09:00
entrez 2005/07/16 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Macgregor S Macgregor Stuart S Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom. macgregors@cf.ac.uk
Knott SA Knott Sara A SA
White I White Ian I
Visscher PM Visscher Peter M PM
INVESTIGATORS
JOURNAL
VOLUME: 171
ISSUE: 3
TITLE: Genetics
ISOABBREVIATION: Genetics
YEAR: 2005
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0016-6731
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genetics
COUNTRY: United States
ISSNLINKING: 0016-6731
NLMUNIQUEID: 0374636
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Genetics. 2004 Mar;166(3):1541-51 15082567
Cites BMC Genet. 2003;4 Suppl 1:S34 14975102
Cites Behav Genet. 1972 Mar;2(1):3-19 4157472
Cites Ann Hum Genet. 1976 May;39(4):485-91 952492
Cites Ann Hum Genet. 1982 Oct;46(Pt 4):373-83 6961886
Cites Genetics. 1990 Apr;124(4):979-93 2323560
Cites Am J Hum Genet. 1990 Aug;47(2):247-54 2378349
Cites Am J Hum Genet. 1990 Dec;47(6):957-67 2239972
Cites Genet Epidemiol. 1991;8(5):299-316 1761203
Cites Am J Hum Genet. 1994 Mar;54(3):535-43 8116623
Cites Biometrics. 1994 Dec;50(4):1171-7 7786999
Cites Genetics. 1995 Jul;140(3):1111-27 7672582
Cites Nat Genet. 1995 Nov;11(3):241-7 7581446
Cites Behav Genet. 1996 Sep;26(5):519-25 8917951
Cites J Dairy Sci. 1997 Jun;80(6):1217-26 9201594
Cites Genetics. 1997 Nov;147(3):1445-57 9383084
Cites Am J Hum Genet. 1998 May;62(5):1198-211 9545414
Cites Am J Hum Genet. 1998 Oct;63(4):1190-201 9758596
Cites Behav Genet. 1998 Sep;28(5):329-40 9926615
Cites Genetics. 2004 Dec;168(4):2383-94 15371347
Cites Genetics. 1999 Oct;153(2):825-35 10610347
Cites Genetics. 2000 Oct;156(2):899-911 11014835
Cites Genetics. 2000 Oct;156(2):913-22 11014836
Cites Genetics. 2000 Dec;156(4):2081-92 11102397
Cites Hum Hered. 2001;51(3):133-44 11173964
Cites Genet Epidemiol. 2002 Mar;22(3):221-32 11921082
Cites Genetics. 2002 Aug;161(4):1751-62 12196415
Cites Am J Hum Genet. 2003 Mar;72(3):561-70 12587094
Cites Am J Hum Genet. 2003 Apr;72(4):949-60 12644967
Cites Hum Hered. 2003;55(1):1-15 12890921
Cites Genet Sel Evol. 2003 Nov-Dec;35(6):605-22 14604510
Cites Genet Epidemiol. 2003;25 Suppl 1:S1-4 14635163
Cites Genet Epidemiol. 2003;25 Suppl 1:S18-28 14635165
Cites BMC Genet. 2003;4 Suppl 1:S17 14975085
Cites BMC Genet. 2003;4 Suppl 1:S21 14975089
Cites BMC Genet. 2003;4 Suppl 1:S22 14975090
Cites BMC Genet. 2003;4 Suppl 1:S23 14975091
Cites BMC Genet. 2003;4 Suppl 1:S24 14975092
Cites BMC Genet. 2003;4 Suppl 1:S29 14975097
Cites Am J Hum Genet. 2004 Sep;75(3):424-35 15266393
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Chromosome Mapping statistics & numerical data
Computer Simulation statistics & numerical data
Humans statistics & numerical data
Models, Genetic statistics & numerical data
Pedigree statistics & numerical data
Quantitative Trait Loci statistics & numerical data
Quantitative Trait, Heritable statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC1456837 NLM
Designed by: GenEpi IT
Maintained by: GenEpi IT
Feedback: webmaster
Copyright © 2007 QIMR
For more information Contact Us
epiit@qimr.edu.au
Last Modified: Oct 15 2007