|
|
| PMID |
|
|
| TITLE |
|
| Protease inhibitor (Pi) locus, fertility and twinning. |
|
| ABSTRACT |
|
|
|
| In a sample of 160 Dutch twin pairs and their parents, we found that mothers of dizygotic twins had frequencies of the S and Z alleles at the protease inhibitor (Pi) locus that were 3 times higher than a control sample. Mothers of identical twins also had a higher frequency of S than controls. The S allele may thus both increase ovulation rate and enhance the success of multiple pregnancies. There was also an increased frequency of the S allele in fathers of dizygotic twins; however, this may be a secondary effect of assortative mating for family size (indicating by the number of siblings of the parents), for which a correlation of 0.2 was observed. Parents of dizygotic twins came from larger families than parents of monozygotic twins, but no effect of Pi type on family size was seen. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
1992/05/01 |
| medline |
1992/05/01 00:01 |
| entrez |
1992/05/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Boomsma DI |
|
Boomsma |
D I |
DI |
|
Department of Psychonomics, Free University, Amsterdam, The Netherlands. |
| Frants RR |
|
Frants |
R R |
RR |
|
|
| Bank RA |
|
Bank |
R A |
RA |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 89 |
| ISSUE: 3 |
| TITLE: Human genetics |
| ISOABBREVIATION: Hum. Genet. |
| YEAR: 1992 |
| MONTH: May |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0340-6717 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Hum Genet |
| COUNTRY: Germany |
| ISSNLINKING: 0340-6717 |
| NLMUNIQUEID: 7613873 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Alleles |
|
| Family Characteristics |
|
| Female |
|
| Fertility |
genetics |
| Gene Frequency |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Phenotype |
genetics |
| Polymorphism, Genetic |
genetics |
| Pregnancy |
genetics |
| Pregnancy, Multiple |
genetics |
| Twins |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
| alpha 1-Antitrypsin |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
alpha 1-Antitrypsin |
|
| OTHER ID's |
|
|
|
