Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
16001363
TITLE
A genomewide scan for intelligence identifies quantitative trait loci on 2q and 6p.
ABSTRACT
Between 40% and 80% of the variation in human intelligence (IQ) is attributable to genetic factors. Except for many rare mutations resulting in severe cognitive dysfunction, attempts to identify these factors have not been successful. We report a genomewide linkage scan involving 634 sibling pairs designed to identify chromosomal regions that explain variation in IQ. Model-free multipoint linkage analysis revealed evidence of a significant quantitative-trait locus for performance IQ at 2q24.1-31.1 (LOD score 4.42), which overlaps the 2q21-33 region that has repeatedly shown linkage to autism. A second region revealed suggestive linkage for both full-scale and verbal IQs on 6p25.3-22.3 (LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 region implicated in reading disability and dyslexia.
DATE PUBLISHED
2005 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2005/04/18
accepted 2005/06/10
aheadofprint 2005/07/01
pubmed 2005/07/08 09:00
medline 2005/09/24 09:00
entrez 2005/07/08 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Posthuma D Posthuma Danielle D Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. danielle@psy.vu.nl
Luciano M Luciano Michelle M
Geus EJ Geus Eco J C de EJ
Wright MJ Wright Margie J MJ
Slagboom PE Slagboom P Eline PE
Montgomery GW Montgomery Grant W GW
Boomsma DI Boomsma Dorret I DI
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 77
ISSUE: 2
TITLE: American journal of human genetics
ISOABBREVIATION: Am. J. Hum. Genet.
YEAR: 2005
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0002-9297
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Hum Genet
COUNTRY: United States
ISSNLINKING: 0002-9297
NLMUNIQUEID: 0370475
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
N01-HG-65403 NHGRI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Autistic Disorder genetics
Chromosome Mapping genetics
Chromosomes, Human, Pair 2 genetics
Chromosomes, Human, Pair 6 genetics
Dyslexia genetics
Female genetics
Genetic Linkage genetics
Genome genetics
Genome, Human genetics
Humans genetics
Intelligence genetics
Learning Disorders genetics
Lod Score genetics
Male genetics
Middle Aged genetics
Mutation genetics
Quantitative Trait Loci genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC1224534 NLM
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