Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15986715
TITLE
Smoking and the genetic contribution to alcohol-dependence risk.
ABSTRACT
Genes influence a person's risk of becoming a smoker as well as the risk of alcohol dependence. Because substantially higher rates of smoking are observed in alcoholics than in control groups, uncovering the mechanisms underlying this association may have important implications for both treatment and prevention. Data analyses from the 1981 Australian twin panel cohort confirm a positive genetic correlation between regular smoking and the risk of alcohol dependence that remains significant, even when sociodemographic and personality variables as well as histories of other psychopathologies are taken into account. Acute or chronic effects of smoking on subjective responses to alcohol may play a role in this association.
DATE PUBLISHED
2000
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2005/07/01 09:00
medline 2005/07/20 09:00
entrez 2005/07/01 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Madden PA Madden P A PA Washington University School ofMedicine in St. Louis, Missouri, USA.
Bucholz KK Bucholz K K KK
Martin NG Martin N G NG
Heath AC Heath A C AC
INVESTIGATORS
JOURNAL
VOLUME: 24
ISSUE: 4
TITLE: Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism
ISOABBREVIATION: Alcohol Res Health
YEAR: 2000
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1535-7414
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Alcohol Res Health
COUNTRY: United States
ISSNLINKING: 1535-7414
NLMUNIQUEID: 100900708
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Review
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA-07728 NIAAA NIH HHS United States
AA-10248 NIAAA NIH HHS United States
AA-11998 NIAAA NIH HHS United States
DA-00272 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alcoholism genetics
Australia epidemiology
Female epidemiology
Humans epidemiology
Male epidemiology
Risk Factors epidemiology
Smoking genetics
Twin Studies as Topic statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's