Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15741437
TITLE
The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
CD14 functions as a multifunctional receptor for bacterial cell wall components including endotoxin and lipopolysaccharide and is likely to play a role in the polarisation of T lymphocytes into Th1 and Th2 subsets, thereby influencing the cytokine profile and subsequent IgE production in response to antigen/allergen contact in allergic phenotypes. A functional C-159T polymorphism has been described in the promoter region of the gene and has been associated with increased gene expression, atopy, and non-atopic asthma in different ethnic populations. A study was undertaken to examine the association between the C-159T polymorphism and asthma, asthma severity, and atopy in a large Australian white population.
METHODS NlmCategory: METHODS
PCR-RFLP analysis was used to characterise the C-159T polymorphism in mild (n = 264), moderate (n = 225) and severe (n = 79) asthmatic patients and non-asthmatic controls (n = 443), including atopic (n = 688) and non-atopic (n = 323) individuals. Association analyses were performed using chi(2) tests.
RESULTS NlmCategory: RESULTS
There was no association between the polymorphism and asthma (p = 0.468) or asthma severity (p = 0.727), and only a very weak association with atopy (p = 0.084). A meta-analysis of all studies conducted to date revealed similar genotypic frequencies in white ethnic populations and confirmed that there was no overall association with atopy (p = 0.52) or asthma (p = 0.23), although there was significant between study heterogeneity (p = 0.01).
CONCLUSIONS NlmCategory: CONCLUSIONS
This study confirms that there is no association between the CD14 C-159T polymorphism and asthma or asthma severity and a weak association between this polymorphism and atopy in an adult population.
DATE PUBLISHED
2005 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2005/03/03 09:00
medline 2005/03/23 09:00
entrez 2005/03/03 09:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kedda MA Kedda M-A MA Asthma and Allergy Research Institute, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia.
Lose F Lose F F
Duffy D Duffy D D
Bell E Bell E E
Thompson PJ Thompson P J PJ
Upham J Upham J J
INVESTIGATORS
JOURNAL
VOLUME: 60
ISSUE: 3
TITLE: Thorax
ISOABBREVIATION: Thorax
YEAR: 2005
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0040-6376
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Thorax
COUNTRY: England
ISSNLINKING: 0040-6376
NLMUNIQUEID: 0417353
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites J Biol Chem. 1997 Feb 14;272(7):4021-6 9020109
Cites Nature. 1996 Sep 19;383(6597):247-50 8805698
Cites Eur Respir J. 1998 Feb;11(2):317-23 9551731
Cites J Biol Chem. 1998 Jul 24;273(30):19294-303 9668119
Cites Hum Genet. 1998 Jul;103(1):57-9 9737777
Cites J Allergy Clin Immunol. 1998 Sep;102(3):449-53 9768587
Cites Am J Respir Crit Care Med. 1998 Dec;158(6):1739-44 9847261
Cites Am J Respir Crit Care Med. 1998 Dec;158(6):1825-30 9847274
Cites Am J Respir Cell Mol Biol. 1999 May;20(5):976-83 10226067
Cites J Allergy Clin Immunol. 1999 Aug;104(2 Pt 1):388-94 10452761
Cites Clin Genet. 1999 Aug;56(2):164-5 10517256
Cites Clin Exp Allergy. 1999 Dec;29 Suppl 4:11-5 10641559
Cites Am J Hum Genet. 2000 Nov;67(5):1154-62 11022011
Cites J Allergy Clin Immunol. 2001 Jan;107(1):31-5 11149987
Cites Am J Respir Crit Care Med. 2001 Mar;163(4):965-9 11282774
Cites Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):20-4 11306916
Cites J Endotoxin Res. 2001;7(1):45-8 11521081
Cites J Immunol. 2001 Nov 15;167(10):5838-44 11698458
Cites Pneumonol Alergol Pol. 2001;69(5-6):265-72 11732288
Cites Am J Respir Crit Care Med. 2001 Dec 1;164(11):2036-44 11739132
Cites Intensive Care Med. 2001 Nov;27(11):1770-5 11810121
Cites Immunol Rev. 2002 Dec;190:9-25 12493003
Cites Clin Exp Allergy. 2003 Feb;33(2):166-9 12580907
Cites J Allergy Clin Immunol. 2003 Aug;112(2):438-44 12897754
Cites Pediatr Allergy Immunol. 2003 Aug;14(4):255-60 12911501
Cites Allergy. 2003 Oct;58(10):1023-6 14510720
Cites Eur J Immunogenet. 2003 Oct;30(5):345-8 14641542
Cites Am J Respir Crit Care Med. 2004 Mar 1;169(5):615-22 14617510
Cites J Allergy Clin Immunol. 2004 May;113(5):889-95 15131571
Cites N Engl J Med. 1989 Feb 2;320(5):271-7 2911321
Cites Clin Exp Allergy. 1989 Jul;19(4):419-24 2758355
Cites Stat Med. 1991 Nov;10(11):1665-77 1792461
Cites Immunol Today. 1992 Oct;13(10):379-81 1418371
Cites Science. 1994 May 20;264(5162):1152-6 8178175
Cites EMBO J. 1994 Aug 15;13(16):3843-51 8070411
Cites Genomics. 1994 Sep 15;23(2):464-70 7835897
Cites J Immunol. 1995 May 15;154(10):5071-9 7730613
Cites J Biol Chem. 1995 May 26;270(21):12737-44 7759528
Cites Annu Rev Immunol. 1995;13:437-57 7542010
Cites Biochemistry. 1995 Dec 19;34(50):16503-8 8845379
Cites Am J Respir Crit Care Med. 1996 Apr;153(4 Pt 1):1280-4 8616554
Cites Infect Immun. 1996 Jun;64(6):1906-12 8675286
Cites Am J Respir Crit Care Med. 1997 Nov;156(5):1390-3 9372650
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Antigens, CD14 genetics
Asthma genetics
Australia epidemiology
Case-Control Studies epidemiology
Genotype epidemiology
Humans epidemiology
Hypersensitivity, Immediate genetics
Odds Ratio genetics
Polymorphism, Genetic genetics
Polymorphism, Restriction Fragment Length genetics
Regression Analysis genetics
Reverse Transcriptase Polymerase Chain Reaction genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Antigens, CD14
OTHER ID's
OTHERID SOURCE
PMC1747323 NLM
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