|
|
| PMID |
|
|
| TITLE |
|
| Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Genetic influences have been shown to play a major role in determining the risk of alcohol dependence (AD) in both women and men; however, little attention has been directed to identifying the major sources of genetic variation in AD risk. |
| METHOD |
NlmCategory: METHODS |
| Diagnostic telephone interview data from young adult Australian twin pairs born between 1964 and 1971 were analyzed. Cox regression models were fitted to interview data from a total of 2708 complete twin pairs (690 MZ female, 485 MZ male, 500 DZ female, 384 DZ male, and 649 DZ female/male pairs). Structural equation models were fitted to determine the extent of residual genetic and environmental influences on AD risk while controlling for effects of sociodemographic and psychiatric predictors on risk. |
| RESULTS |
NlmCategory: RESULTS |
| Risk of AD was increased in males, in Roman Catholics, in those reporting a history of major depression, social anxiety problems, and conduct disorder, or (in females only) a history of suicide attempt and childhood sexual abuse; but was decreased in those reporting Baptist, Methodist, or Orthodox religion, in those who reported weekly church attendance, and in university-educated males. After allowing for the effects of sociodemographic and psychiatric predictors, 47 % (95% CI 28-55) of the residual variance in alcoholism risk was attributable to additive genetic effects, 0% (95% CI 0-14) to shared environmental factors, and 53% (95% CI 45-63) to nonshared environmental influences. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Controlling for other risk factors, substantial residual heritability of AD was observed, suggesting that psychiatric and other risk factors play a minor role in the inheritance of AD. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2005/02/24 09:00 |
| medline |
2005/04/20 09:00 |
| entrez |
2005/02/24 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Knopik VS |
|
Knopik |
Valerie S |
VS |
|
Missouri Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA. vsknopik@matlock.wustl.edu |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
|
| Slutske WS |
|
Slutske |
Wendy S |
WS |
|
|
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
|
| Statham D |
|
Statham |
Dixie |
D |
|
|
| Whitfield JB |
|
Whitfield |
John B |
JB |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 34 |
| ISSUE: 8 |
| TITLE: Psychological medicine |
| ISOABBREVIATION: Psychol Med |
| YEAR: 2004 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0033-2917 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Psychol Med |
| COUNTRY: England |
| ISSNLINKING: 0033-2917 |
| NLMUNIQUEID: 1254142 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA0758O |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Alcoholism |
psychology |
| Anxiety Disorders |
complications |
| Australia |
complications |
| Child |
complications |
| Child Abuse, Sexual |
complications |
| Depression |
complications |
| Female |
complications |
| Humans |
complications |
| Male |
complications |
| Mental Disorders |
genetics |
| Regression Analysis |
genetics |
| Risk Factors |
genetics |
| Suicide, Attempted |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
