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|
| PMID |
|
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| TITLE |
|
| Bladder neck mobility is a heritable trait. |
|
| ABSTRACT |
|
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| Congenital connective tissue dysfunction may partly be responsible for female pelvic organ prolapse and urinary incontinence. We undertook a heritability study to determine whether mobility of the bladder neck, one of the main determinants of stress urinary incontinence, is genetically influenced. |
| DESIGN |
NlmCategory: METHODS |
| Heritability study using a twin model and structural equation modelling. |
| SETTING |
NlmCategory: METHODS |
| Queensland Institute of Medical Research, Brisbane, Australia. |
| POPULATION |
NlmCategory: METHODS |
| One hundred and seventy-eight nulliparous Caucasian female twins and their sisters (46 monozygotic pairs, 24 dizygotic pairs and 38 sisters) aged 18-24 years. |
| METHODS |
NlmCategory: METHODS |
| We performed translabial ultrasound, supine and after bladder emptying, for pelvic organ mobility. Urethral rotation and bladder neck descent were calculated using the best of three effective Valsalva manoeuvres. |
| MAIN OUTCOME MEASURES |
NlmCategory: METHODS |
| Bladder and urethral mobility on Valsalva assessed by urethral rotation, vertical and oblique bladder neck descent. |
| RESULTS |
NlmCategory: RESULTS |
| Genetic modelling indicated that additive genes accounted for up to 59% of the variance for bladder neck descent. All remaining variance appeared due to environmental influences unique to the individual, including measurement error. |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| A significant genetic contribution to the phenotype of bladder neck mobility appears likely. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2005/02/17 09:00 |
| medline |
2005/03/16 09:00 |
| entrez |
2005/02/17 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Dietz HP |
|
Dietz |
H P |
HP |
|
University of Sydney, NSW 2751, Australia. |
| Hansell NK |
|
Hansell |
N K |
NK |
|
|
| Grace ME |
|
Grace |
M E |
ME |
|
|
| Eldridge AM |
|
Eldridge |
A M |
AM |
|
|
| Clarke B |
|
Clarke |
B |
B |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 112 |
| ISSUE: 3 |
| TITLE: BJOG : an international journal of obstetrics and gynaecology |
| ISOABBREVIATION: BJOG |
| YEAR: 2005 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1470-0328 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: BJOG |
| COUNTRY: England |
| ISSNLINKING: 1470-0328 |
| NLMUNIQUEID: 100935741 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Age Factors |
|
| Analysis of Variance |
|
| Environment |
|
| Female |
|
| Heredity |
physiology |
| Humans |
physiology |
| Movement |
physiology |
| Pelvic Floor |
physiology |
| Phenotype |
physiology |
| Prolapse |
physiology |
| Urethra |
ultrasonography |
| Urinary Bladder |
ultrasonography |
| Urinary Incontinence |
genetics |
| Valsalva Maneuver |
genetics |
|
| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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