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| PMID |
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| TITLE |
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| Multivariate genetic analysis of chronic pelvic pain and associated phenotypes. |
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| ABSTRACT |
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| Chronic pelvic pain (CPP) is a common condition in women that is difficult to diagnose. Although heritability estimates have been published for some conditions potentially underlying pelvic pain, the heritability of CPP itself has never been investigated. Using data from 623 MZ and 377 DZ female twin pairs aged 29-50 from an Australian twin cohort, we found an increased CPP concordance among MZs compared to DZs, with tetrachoric correlations of 0.43 (95% CI: 0.26-0.58) and 0.11 (95% CI: -0.16-0.38), respectively. This corresponded to a heritability of 0.41 (95% CI: 0.25-0.56). Lack of correlations with environmental indicators suggested that violation of the equal environments assumption was not responsible for this effect. Multivariate Cholesky decomposition models incorporating CPP and significantly correlated phenotypes showed that the entire CPP heritability could be explained by genetic variance underlying endometriosis (38%), dysmenorrhoea (23%), fibroids (24%), and somatic distress (15%), the latter a possible indicator of increased nociception. CPP itself is unlikely to be a useful independent phenotype to conduct genetic aetiological studies; contributing conditions such as endometriosis and variation in nociception are likely to provide more useful phenotypes. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2004/05/26 |
| accepted |
2004/09/13 |
| pubmed |
2005/02/03 09:00 |
| medline |
2005/04/15 09:00 |
| entrez |
2005/02/03 09:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Zondervan KT |
|
Zondervan |
Krina T |
KT |
|
Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, United Kingdom. Krinaz@well.ox.ac.uk |
| Cardon LR |
|
Cardon |
Lon R |
LR |
|
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| Kennedy SH |
|
Kennedy |
Stephen H |
SH |
|
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| Martin NG |
|
Martin |
Nicholas G |
NG |
|
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| Treloar SA |
|
Treloar |
Susan A |
SA |
|
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 35 |
| ISSUE: 2 |
| TITLE: Behavior genetics |
| ISOABBREVIATION: Behav. Genet. |
| YEAR: 2005 |
| MONTH: Mar |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0001-8244 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Behav Genet |
| COUNTRY: United States |
| ISSNLINKING: 0001-8244 |
| NLMUNIQUEID: 0251711 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
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| Analysis of Variance |
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| Chronic Disease |
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| Female |
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| Humans |
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| Models, Genetic |
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| Multivariate Analysis |
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| Pelvic Pain |
genetics |
| Phenotype |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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