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| PMID |
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| TITLE |
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| Linkage analysis: principles and methods for the analysis of human quantitative traits. |
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| ABSTRACT |
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| Currently, mapping genes for complex human traits relies on two complementary approaches, linkage and association analyses. Both suffer from several methodological and theoretical limitations, which can considerably increase the type-1 error rate and reduce the power to map human quantitative trait loci (QTL). This review focuses on linkage methods for QTL mapping. It summarizes the most common linkage statistics used, namely Haseman-Elston-based methods, variance components, and statistics that condition on trait values. Methods developed more recently that accommodate the X-chromosome, parental imprinting and allelic association in linkage analysis are also summarized. The type-I error rate and power of these methods are discussed. Finally, rough guidelines are provided to help guide the choice of linkage statistics. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2004/11/06 09:00 |
| medline |
2005/03/25 09:00 |
| entrez |
2004/11/06 09:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ferreira MA |
|
Ferreira |
Manuel A R |
MA |
|
Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Australia. manuelF@qimr.edu.au |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 7 |
| ISSUE: 5 |
| TITLE: Twin research : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res |
| YEAR: 2004 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1369-0523 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res |
| COUNTRY: Australia |
| ISSNLINKING: 1369-0523 |
| NLMUNIQUEID: 9815819 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Genetic Linkage |
genetics |
| Genotype |
genetics |
| Humans |
genetics |
| Models, Genetic |
genetics |
| Models, Statistical |
genetics |
| Phenotype |
genetics |
| Quantitative Trait Loci |
genetics |
| Quantitative Trait, Heritable |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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