|
|
| PMID |
|
|
| TITLE |
|
| Major quantitative trait locus for eosinophil count is located on chromosome 2q. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Eosinophils are granulocytic white blood cells implicated in asthma and atopic disease. The degree of eosinophilia in the blood of patients with asthma correlates with the severity of asthmatic symptoms. Quantitative trait loci (QTL) linkage analysis of eosinophil count may be a more powerful strategy of mapping genes involved in asthma than linkage analysis using affected relative pairs. |
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| To identify QTLs responsible for variation in eosinophil count in adolescent twins. |
| METHODS |
NlmCategory: METHODS |
| We measured eosinophil count longitudinally in 738 pairs of twins at 12, 14, and 16 years of age. We typed 757 highly polymorphic microsatellite markers at an average spacing of approximately 5 centimorgans across the genome. We then used multipoint variance components linkage analysis to test for linkage between marker loci and eosinophil concentrations at each age across the genome. |
| RESULTS |
NlmCategory: RESULTS |
| We found highly significant linkage on chromosome 2q33 in 12-year-old twins (logarithm of the odds=4.6; P=.000002) and suggestive evidence of linkage in the same region in 14-year-olds (logarithm of the odds=1.0; P=.016). We also found suggestive evidence of linkage at other areas of the genome, including regions on chromosomes 2, 3, 4, 8, 9, 11, 12, 17, 20, and 22. |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| A QTL for eosinophil count is present on chromosome 2q33. This QTL might represent a gene involved in asthma pathophysiology. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2004/10/14 09:00 |
| medline |
2004/12/31 09:00 |
| entrez |
2004/10/14 09:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Evans DM |
|
Evans |
David M |
DM |
|
Queensland Institute of Medical Research and Joint Genetics Program, University of Queensland, Brisbane, Australia. davide@well.ox.ac.uk |
| Zhu G |
|
Zhu |
Gu |
G |
|
|
| Duffy DL |
|
Duffy |
David L |
DL |
|
|
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
|
| Frazer IH |
|
Frazer |
Ian H |
IH |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
|
| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 114 |
| ISSUE: 4 |
| TITLE: The Journal of allergy and clinical immunology |
| ISOABBREVIATION: J. Allergy Clin. Immunol. |
| YEAR: 2004 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0091-6749 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Allergy Clin Immunol |
| COUNTRY: United States |
| ISSNLINKING: 0091-6749 |
| NLMUNIQUEID: 1275002 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| CA88363 |
NCI NIH HHS |
United States |
|
| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Child |
|
| Chromosome Mapping |
methods |
| Chromosomes, Human, Pair 2 |
genetics |
| Eosinophils |
physiology |
| Female |
physiology |
| Humans |
physiology |
| Male |
physiology |
| Quantitative Trait Loci |
genetics |
| Twins |
genetics |
|
| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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|
