Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
15169605
TITLE
Using identity-by-descent information in affected sib pairs to increase the efficiency of genetic association studies.
ABSTRACT
The aim of this study was to determine whether identity-by-descent (IBD) information for affected sib pairs (ASPs) can be used to select a sample of cases for a genetic case-control study which will provide more power for detecting association with loci in a known linkage region. By modeling the expected frequency of the disease allele in ASPs showing IBD sharing of 0, 1, or 2 alleles, and considering additive, recessive, and dominant disease models, we show that cases selected from IBD 2 families are best for this purpose, followed by those selected from IBD 1 families; least useful are cases selected from IBD 0 families.
DATE PUBLISHED
2004 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2004/06/01 05:00
medline 2004/07/28 05:00
entrez 2004/06/01 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wicks J Wicks Jacqueline J Queensland Institute of Medical Research, Brisbane, Australia. jackiW@qimr.edu.au
Treloar SA Treloar Susan A SA
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 7
ISSUE: 2
TITLE: Twin research : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res
YEAR: 2004
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1369-0523
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res
COUNTRY: Australia
ISSNLINKING: 1369-0523
NLMUNIQUEID: 9815819
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alleles
Case-Control Studies
Genetic Linkage genetics
Genetic Predisposition to Disease genetics
Humans genetics
Lod Score genetics
Models, Genetic genetics
Outcome Assessment (Health Care) genetics
Siblings genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's