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| PMID |
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| TITLE |
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| Using identity-by-descent information in affected sib pairs to increase the efficiency of genetic association studies. |
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| ABSTRACT |
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| The aim of this study was to determine whether identity-by-descent (IBD) information for affected sib pairs (ASPs) can be used to select a sample of cases for a genetic case-control study which will provide more power for detecting association with loci in a known linkage region. By modeling the expected frequency of the disease allele in ASPs showing IBD sharing of 0, 1, or 2 alleles, and considering additive, recessive, and dominant disease models, we show that cases selected from IBD 2 families are best for this purpose, followed by those selected from IBD 1 families; least useful are cases selected from IBD 0 families. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2004/06/01 05:00 |
| medline |
2004/07/28 05:00 |
| entrez |
2004/06/01 05:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Wicks J |
|
Wicks |
Jacqueline |
J |
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Queensland Institute of Medical Research, Brisbane, Australia. jackiW@qimr.edu.au |
| Treloar SA |
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Treloar |
Susan A |
SA |
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| Martin NG |
|
Martin |
Nicholas G |
NG |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 7 |
| ISSUE: 2 |
| TITLE: Twin research : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res |
| YEAR: 2004 |
| MONTH: Apr |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1369-0523 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res |
| COUNTRY: Australia |
| ISSNLINKING: 1369-0523 |
| NLMUNIQUEID: 9815819 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Alleles |
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| Case-Control Studies |
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| Genetic Linkage |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Humans |
genetics |
| Lod Score |
genetics |
| Models, Genetic |
genetics |
| Outcome Assessment (Health Care) |
genetics |
| Siblings |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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