Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
14993113
TITLE
Genetic epidemiology of alcohol-induced blackouts.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention.
OBJECTIVE NlmCategory: OBJECTIVE
Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention. To examine the genetic epidemiology of lifetime blackouts and having had 3 or more blackouts in a year, including analyses controlling for the frequency of intoxication.
DESIGN, SETTING, AND PARTICIPANTS NlmCategory: METHODS
Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention. To examine the genetic epidemiology of lifetime blackouts and having had 3 or more blackouts in a year, including analyses controlling for the frequency of intoxication. Members of the young adult Australian Twin Register, a volunteer twin panel born between January 1, 1964, and December 31, 1971, were initially registered with the panel as children by their parents between 1980 and 1982. They underwent structured psychiatric telephone interviews from February 1996 through September 2000. The current sample contains 2324 monozygotic and dizygotic twin pairs (mean [SD] age 29.9 [2.5] years) for whom both twins' responses were coded for blackout questions and for frequency of intoxication.
MAIN OUTCOME MEASURE NlmCategory: METHODS
Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention. To examine the genetic epidemiology of lifetime blackouts and having had 3 or more blackouts in a year, including analyses controlling for the frequency of intoxication. Members of the young adult Australian Twin Register, a volunteer twin panel born between January 1, 1964, and December 31, 1971, were initially registered with the panel as children by their parents between 1980 and 1982. They underwent structured psychiatric telephone interviews from February 1996 through September 2000. The current sample contains 2324 monozygotic and dizygotic twin pairs (mean [SD] age 29.9 [2.5] years) for whom both twins' responses were coded for blackout questions and for frequency of intoxication. Outcome Measure Data on lifetime blackouts and having had 3 or more blackouts in a year were collected within an examination of the genetic epidemiology of alcoholism.
RESULTS NlmCategory: RESULTS
Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention. To examine the genetic epidemiology of lifetime blackouts and having had 3 or more blackouts in a year, including analyses controlling for the frequency of intoxication. Members of the young adult Australian Twin Register, a volunteer twin panel born between January 1, 1964, and December 31, 1971, were initially registered with the panel as children by their parents between 1980 and 1982. They underwent structured psychiatric telephone interviews from February 1996 through September 2000. The current sample contains 2324 monozygotic and dizygotic twin pairs (mean [SD] age 29.9 [2.5] years) for whom both twins' responses were coded for blackout questions and for frequency of intoxication. Outcome Measure Data on lifetime blackouts and having had 3 or more blackouts in a year were collected within an examination of the genetic epidemiology of alcoholism. A lifetime history of blackouts was reported by 39.3% of women and 52.4% of men; 11.4% of women and 20.9% of men reported having had 3 or more blackouts in a year. The heritability of lifetime blackouts was 52.5% and that of having had 3 or more blackouts in a year was 57.8%. Models that controlled for frequency of intoxication found evidence of substantial genetic contribution unique to risk for the blackouts and a significant component of genetic risk shared with frequency of intoxication.
CONCLUSIONS NlmCategory: CONCLUSIONS
Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention. To examine the genetic epidemiology of lifetime blackouts and having had 3 or more blackouts in a year, including analyses controlling for the frequency of intoxication. Members of the young adult Australian Twin Register, a volunteer twin panel born between January 1, 1964, and December 31, 1971, were initially registered with the panel as children by their parents between 1980 and 1982. They underwent structured psychiatric telephone interviews from February 1996 through September 2000. The current sample contains 2324 monozygotic and dizygotic twin pairs (mean [SD] age 29.9 [2.5] years) for whom both twins' responses were coded for blackout questions and for frequency of intoxication. Outcome Measure Data on lifetime blackouts and having had 3 or more blackouts in a year were collected within an examination of the genetic epidemiology of alcoholism. A lifetime history of blackouts was reported by 39.3% of women and 52.4% of men; 11.4% of women and 20.9% of men reported having had 3 or more blackouts in a year. The heritability of lifetime blackouts was 52.5% and that of having had 3 or more blackouts in a year was 57.8%. Models that controlled for frequency of intoxication found evidence of substantial genetic contribution unique to risk for the blackouts and a significant component of genetic risk shared with frequency of intoxication. The finding of a substantial genetic contribution to liability for alcohol-induced blackouts including a component of genetic loading shared with frequency of intoxication may offer important additional avenues to investigate susceptibility to alcohol-related problems.
DATE PUBLISHED
2004 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2004/03/03 05:00
medline 2004/03/31 05:00
entrez 2004/03/03 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Nelson EC Nelson Elliot C EC Department of Psychiatry, Washington University School of Medicine and St Louis University School of Public Health, St Louis, O 63108, USA. nelsone@psychiatry.wustl.edu
Heath AC Heath Andrew C AC
Bucholz KK Bucholz Kathleen K KK
Madden PA Madden Pamela A F PA
Fu Q Fu Qiang Q
Knopik V Knopik Valerie V
Lynskey MT Lynskey Michael T MT
Lynskey MT Lynskey Michael T MT
Whitfield JB Whitfield John B JB
Statham DJ Statham Dixie J DJ
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME: 61
ISSUE: 3
TITLE: Archives of general psychiatry
ISOABBREVIATION: Arch Gen Psychiatry
YEAR: 2004
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0003-990X
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Arch Gen Psychiatry
COUNTRY: United States
ISSNLINKING: 0003-990X
NLMUNIQUEID: 0372435
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
94177 PHS HHS United States
981351 PHS HHS United States
AA00277 NIAAA NIH HHS United States
AA07728 NIAAA NIH HHS United States
AA10249 NIAAA NIH HHS United States
AA11998 NIAAA NIH HHS United States
AA13321 NIAAA NIH HHS United States
AA13326 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Alcoholic Intoxication genetics
Alcoholism genetics
Amnesia, Anterograde genetics
Female genetics
Genetic Predisposition to Disease genetics
Humans genetics
Incidence genetics
Male genetics
Risk Factors genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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