Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
14982597
TITLE
Inflammation in allergic asthma: initiating events, immunological response and risk factors.
ABSTRACT
Allergic asthma affects 155 million people worldwide. Currently, it is a disease that can be controlled by diverse therapeutic approaches but that cannot be cured. This means that asthma is one of the most expensive diseases for healthcare systems in developed countries. Efficient prevention strategies are therefore greatly needed to reduce both individual morbidity and national economic burdens. This requires a detailed knowledge of the immunological and physiological mechanisms involved in asthma. This review synthesizes current understanding about the immunobiology of IgE-mediated asthma. It discusses the initiating events, the main immunological and inflammatory processes, and addresses the importance of risk factors in the development and maintenance of allergic diseases. Finally, it integrates these concepts in a theoretical causal model for atopic asthma.
DATE PUBLISHED
2004 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2004/02/26 05:00
medline 2004/08/27 05:00
entrez 2004/02/26 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ferreira MA Ferreira Manuel A R MA Queensland Institute of Medical Research, Brisbane, Queensland, Australia. manuelF@qimr.edu.au
INVESTIGATORS
JOURNAL
VOLUME: 9
ISSUE: 1
TITLE: Respirology (Carlton, Vic.)
ISOABBREVIATION: Respirology
YEAR: 2004
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1323-7799
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Respirology
COUNTRY: Australia
ISSNLINKING: 1323-7799
NLMUNIQUEID: 9616368
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Asthma physiopathology
CD4-Positive T-Lymphocytes immunology
Humans immunology
Immunity, Cellular immunology
Inflammation physiopathology
Phenotype physiopathology
Risk Factors physiopathology
Th2 Cells physiopathology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's