Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
14975090
TITLE
Longitudinal variance-components analysis of the Framingham Heart Study data.
ABSTRACT
The Framingham Heart Study offspring cohort, a complex data set with irregularly spaced longitudinal phenotype data, was made available as part of Genetic Analysis Workshop 13. To allow an analysis of all of the data simultaneously, a mixed-model- based random-regression (RR) approach was used. The RR accounted for the variation in genetic effects (including marker-specific quantitative trait locus (QTL) effects) across time by fitting polynomials of age. The use of a mixed model allowed both fixed (such as sex) and random (such as familial environment) effects to be accounted for appropriately. Using this method we performed a QTL analysis of all of the available adult phenotype data (26,106 phenotypic records). In addition to RR, conventional univariate variance component techniques were applied. The traits of interest were BMI, HDLC, total cholesterol, and height. The longitudinal method allowed the characterization of the change in QTL effects with aging. A QTL affecting BMI was shown to act mainly at early ages.
DATE PUBLISHED
2003
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2004/02/21 05:00
medline 2004/04/30 05:00
epublish 2003/00/31
entrez 2004/02/21 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Macgregor S Macgregor Stuart S Biostatistics and Bioinformatics Unit, University of Wales College of Medicine, Heath Hospital, Cardiff, United Kingdom. smacgreg@hgmp.mrc.ac.uk
Knott SA Knott Sara A SA
White I White Ian I
Visscher PM Visscher Peter M PM
Framingham Heart Study
INVESTIGATORS
JOURNAL
VOLUME: 4 Suppl 1
ISSUE:
TITLE: BMC genetics
ISOABBREVIATION: BMC Genet.
YEAR: 2003
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1471-2156
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: BMC Genet
COUNTRY: England
ISSNLINKING: 1471-2156
NLMUNIQUEID: 100966978
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Genetics. 1999 Oct;153(2):825-35 10610347
Cites Am J Hum Genet. 1998 May;62(5):1198-211 9545414
Cites Genetics. 2000 Oct;156(2):913-22 11014836
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Adult Children
Age Factors
Aged
Aged, 80 and over
Cardiovascular Diseases genetics
Chromosome Mapping methods
Chromosomes, Human, Pair 12 genetics
Chromosomes, Human, Pair 16 genetics
Chromosomes, Human, Pair 20 genetics
Data Interpretation, Statistical genetics
Female genetics
Humans genetics
Linkage Disequilibrium genetics
Longitudinal Studies genetics
Male genetics
Middle Aged genetics
Models, Statistical genetics
Multifactorial Inheritance genetics
Multivariate Analysis genetics
Quantitative Trait Loci genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC1866457 NLM