Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
14760932
TITLE
Cytokine expression in allergic inflammation: systematic review of in vivo challenge studies.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
Allergic inflammatory responses are driven by cells of the immune system that rely on cytokines to regulate the activity of other immune and structural cells.
OBJECTIVE NlmCategory: OBJECTIVE
To review published studies to (1) identify cytokines consistently increased after allergen challenge in atopic patients and (2) investigate temporal variation in cytokine expression.
METHODS NlmCategory: METHODS
A PUBMED systematic search was used to extract data from studies involving analysis of cytokine expression in fluids or biopsies following in vivo allergen challenge in atopic patients.
RESULTS NlmCategory: RESULTS
Data were extracted from 82 studies. There were no consistent reports of cytokine protein increase in fluids of patients at 0-1 h after challenge. At 4-12 h, the chemokines eotaxin, macrophage inflammatory protein-1alpha, RANTES (regulated on activation normal T cell expressed and secreted) and interleukin (IL)-8 have all been consistently reported to be up-regulated. At 18-24 h after challenge, the lymphokines IL-4, IL-5 and IL-13, as well as the pro-inflammatory cytokines granulocyte-macrophage colony-stimulating factor, tumour necrosis factor-alpha and IL-6 are consistently increased when compared with the respective control value. There were no reports of up-regulation in interferon-gamma protein and mRNA and in IL-2 mRNA.
CONCLUSION NlmCategory: CONCLUSIONS
The expression of granulocyte-macrophage colony-stimulating factor is consistently increased in tissues at 4-12 h after challenge. The influence of this cytokine on antigen capture and presentation by dendritic cells should be further investigated. Additionally, allergen challenge studies are needed that investigate the expression of macrophage-derived chemokine and thymus-regulated and activation-regulated chemokine in tissues of atopic patients. Blocking the effects of these lymphocyte-specific chemokines might provide new therapeutic approaches for the control of allergic inflammation.
DATE PUBLISHED
2003 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2004/02/06 05:00
medline 2004/04/07 05:00
entrez 2004/02/06 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Ferreira MA Ferreira Manuel A R MA Queensland Institute of Medical Research, P.O. Royal Brisbane Hospital, Brisbane 4029, Australia. manuelF@qimr.edu.au
INVESTIGATORS
JOURNAL
VOLUME: 12
ISSUE: 5
TITLE: Mediators of inflammation
ISOABBREVIATION: Mediators Inflamm.
YEAR: 2003
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0962-9351
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Mediators Inflamm
COUNTRY: England
ISSNLINKING: 0962-9351
NLMUNIQUEID: 9209001
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Review
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Allergens immunology
Cytokines metabolism
Humans metabolism
Hypersensitivity metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Allergens
0 Cytokines
OTHER ID's
OTHERID SOURCE
PMC1781628 NLM