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PMID |
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TITLE |
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Event-related potential correlates of impaired visuospatial working memory in schizophrenia. |
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ABSTRACT |
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Previous studies have reported that patients with schizophrenia demonstrate impaired performance during working memory (WM) tasks. The current study aimed to determine whether WM impairments in schizophrenia are accompanied by reduced slow wave (SW) activity during on-line maintenance of mnemonic information. Event-related potentials were obtained from patients with schizophrenia and well controls as they performed a visuospatial delayed response task. On 50% of trials, a distractor stimulus was introduced during the delay. Compared with controls, patients with schizophrenia produced less SW memory negativity, particularly over the right hemisphere, together with reduced frontal enhancement of SW memory negativity in response to distraction. The results indicate that patients with schizophrenia generate less maintenance phase neuronal activity during WM performance, especially under conditions of distraction. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pubmed |
2003/12/31 05:00 |
medline |
2004/01/30 05:00 |
entrez |
2003/12/31 05:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Cameron AM |
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Cameron |
Allison M |
AM |
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Cognitive Psychophysiology Laboratory, Medical School, The University of Queensland, Herston, Queensland, Australia. allison@psy.uq.edu.au |
Geffen GM |
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Geffen |
Gina M |
GM |
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Kavanagh DJ |
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Kavanagh |
David J |
DJ |
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Wright MJ |
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Wright |
Margie J |
MJ |
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McGrath JJ |
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McGrath |
John J |
JJ |
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Geffen LB |
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Geffen |
Laurie B |
LB |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 40 |
ISSUE: 5 |
TITLE: Psychophysiology |
ISOABBREVIATION: Psychophysiology |
YEAR: 2003 |
MONTH: Sep |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 0048-5772 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Psychophysiology |
COUNTRY: United States |
ISSNLINKING: 0048-5772 |
NLMUNIQUEID: 0142657 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Clinical Trial |
Journal Article |
Research Support, Non-U.S. Gov't |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
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Evoked Potentials |
physiology |
Female |
physiology |
Humans |
physiology |
Male |
physiology |
Memory, Short-Term |
physiology |
Neurons |
physiology |
Psychomotor Performance |
physiology |
Schizophrenic Psychology |
physiology |
Space Perception |
physiology |
Visual Perception |
physiology |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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