Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
14696724
TITLE
Event-related potential correlates of impaired visuospatial working memory in schizophrenia.
ABSTRACT
Previous studies have reported that patients with schizophrenia demonstrate impaired performance during working memory (WM) tasks. The current study aimed to determine whether WM impairments in schizophrenia are accompanied by reduced slow wave (SW) activity during on-line maintenance of mnemonic information. Event-related potentials were obtained from patients with schizophrenia and well controls as they performed a visuospatial delayed response task. On 50% of trials, a distractor stimulus was introduced during the delay. Compared with controls, patients with schizophrenia produced less SW memory negativity, particularly over the right hemisphere, together with reduced frontal enhancement of SW memory negativity in response to distraction. The results indicate that patients with schizophrenia generate less maintenance phase neuronal activity during WM performance, especially under conditions of distraction.
DATE PUBLISHED
2003 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2003/12/31 05:00
medline 2004/01/30 05:00
entrez 2003/12/31 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Cameron AM Cameron Allison M AM Cognitive Psychophysiology Laboratory, Medical School, The University of Queensland, Herston, Queensland, Australia. allison@psy.uq.edu.au
Geffen GM Geffen Gina M GM
Kavanagh DJ Kavanagh David J DJ
Wright MJ Wright Margie J MJ
McGrath JJ McGrath John J JJ
Geffen LB Geffen Laurie B LB
INVESTIGATORS
JOURNAL
VOLUME: 40
ISSUE: 5
TITLE: Psychophysiology
ISOABBREVIATION: Psychophysiology
YEAR: 2003
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0048-5772
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Psychophysiology
COUNTRY: United States
ISSNLINKING: 0048-5772
NLMUNIQUEID: 0142657
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Evoked Potentials physiology
Female physiology
Humans physiology
Male physiology
Memory, Short-Term physiology
Neurons physiology
Psychomotor Performance physiology
Schizophrenic Psychology physiology
Space Perception physiology
Visual Perception physiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's