Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
14574138
TITLE
Direction of causation modeling between cross-sectional measures of parenting and psychological distress in female twins.
ABSTRACT
Under certain conditions, cross-sectional analysis of cross-twin intertrait correlations can provide important information about the direction of causation (DOC) between two variables. A community-based sample of Australian female twins aged 18 to 45 years was mailed an extensive Health and Lifestyle Questionnaire (HLQ) that covered a wide range of personality and behavioral measures. Included were self-report measures of recent psychological distress and perceived childhood environment (PBI). Factor analysis of the PBI yielded three interpretable dimensions: Coldness, Overprotection, and Autonomy. Univariate analysis revealed that parental Overprotection and Autonomy were best explained by additive genetic, shared, and nonshared environmental effects (ACE), whereas the best-fitting model for PBI Coldness and the three measures of psychological distress (Depression, Phobic Anxiety, and Somatic Distress) included only additive genetic and nonshared environmental effects (AE). A common pathway model best explained the covariation between (1) the three PBI dimensions and (2) the three measures of psychological distress. DOC modeling between latent constructs of parenting and psychological distress revealed that a model which specified recollected parental behavior as the cause of psychological distress provided a better fit than a model which specified psychological distress as the cause of recollected parental behavior. Power analyses and limitations of the findings are discussed.
DATE PUBLISHED
2003 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2003/10/24 05:00
medline 2003/12/10 05:00
entrez 2003/10/24 05:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Gillespie NA Gillespie Nathan A NA Genetic Epidemiology Unit, Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia. nathanG@qimr.edu.au
Zhu G Zhu Gu G
Neale MC Neale Michael C MC
Heath AC Heath Andrew C AC
Martin NG Martin Nicolas G NG
INVESTIGATORS
JOURNAL
VOLUME: 33
ISSUE: 4
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2003
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA 07535 NIAAA NIH HHS United States
AA 07728 NIAAA NIH HHS United States
AA 10249 NIAAA NIH HHS United States
AA 11998 NIAAA NIH HHS United States
AA 13321 NIAAA NIH HHS United States
AA 13326 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Australia
Cohort Studies
Demography
Female
Humans
Middle Aged
Models, Genetic
Parenting
Questionnaires
Registries
Stress, Psychological genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's