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| PMID |
|
|
| TITLE |
|
| Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels. |
|
| ABSTRACT |
|
|
|
| Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs. |
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| DATE PUBLISHED |
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| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2003/09/27 05:00 |
| medline |
2005/02/03 09:00 |
| entrez |
2003/09/27 05:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Beekman M |
|
Beekman |
Marian |
M |
|
Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. M.Beekman@lumc.nl. |
| Heijmans BT |
|
Heijmans |
Bastiaan T |
BT |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Whitfield JB |
|
Whitfield |
John B |
JB |
|
|
| Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
|
| DeFaire U |
|
DeFaire |
Ulf |
U |
|
|
| Snieder H |
|
Snieder |
Harold |
H |
|
|
| Lakenberg N |
|
Lakenberg |
Nico |
N |
|
|
| de Knijff P |
|
de Knijff |
Peter |
P |
|
|
| Frants RR |
|
Frants |
Rune R |
RR |
|
|
| van Ommen GJ |
|
van Ommen |
Gert Jan B |
GJ |
|
|
| Kluft C |
|
Kluft |
Cornelis |
C |
|
|
| Vogler GP |
|
Vogler |
George P |
GP |
|
|
| Slagboom PE |
|
Slagboom |
P Eline |
PE |
|
|
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 6 |
| ISSUE: 4 |
| TITLE: Twin research : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res |
| YEAR: 2003 |
| MONTH: Aug |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1369-0523 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res |
| COUNTRY: Australia |
| ISSNLINKING: 1369-0523 |
| NLMUNIQUEID: 9815819 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AG04563 |
NIA NIH HHS |
United States |
| HL55976 |
NHLBI NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Chromosomes, Human, Pair 1 |
|
| Chromosomes, Human, Pair 6 |
|
| Genetic Linkage |
|
| Humans |
|
| Lipoproteins |
genetics |
| Quantitative Trait Loci |
genetics |
| Twins |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Lipoproteins |
|
| OTHER ID's |
|
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|
