Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
1442963
TITLE
Pathways to hysterectomy: insights from longitudinal twin research.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
We hypothesized that genetic influences act on "liability" to hysterectomy, that secular influences might differentially affect relative importance of genetic and environmental influences, and that the sources of genetic influences could be identified from reported risk factors.
STUDY DESIGN NlmCategory: METHODS
Hysterectomy data from an Australia-wide volunteer sample of female adult monozygotic and dizygotic twins are reported. In 1980 through 1982 a mailed questionnaire was completed by 1232 monozygotic female twin pairs and 751 dizygotic female twin pairs (3966 women) from the Australian Twin Register (wave 1). The same twins were surveyed by questionnaire 8 years later (wave 2).
RESULTS NlmCategory: RESULTS
A total of 366 had undergone hysterectomy by wave 1 and a further 198 at wave 2. The twin-pair correlations for liability to hysterectomy at wave 1 (0.61 +/- 0.06 for monozygotic and 0.20 +/- 0.11 for dizygotic) and wave 2 (0.65 +/- 0.05 for monozygotic and 0.32 +/- 0.09 for monozygotic) indicated a substantial genetic contribution. Reported risk factors accounted for only 15% of total variance.
CONCLUSION NlmCategory: CONCLUSIONS
Genetic influences on liability to hysterectomy were substantial and stable across birth cohorts, but the important sources of genetic influence on liability to hysterectomy are yet to be identified.
DATE PUBLISHED
1992 Jul
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 1992/07/01
medline 1992/07/01 00:01
entrez 1992/07/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Treloar SA Treloar S A SA Queensland Institute of Medical Research, Brisbane, Australia.
Martin NG Martin N G NG
Dennerstein L Dennerstein L L
Raphael B Raphael B B
Heath AC Heath A C AC
INVESTIGATORS
JOURNAL
VOLUME: 167
ISSUE: 1
TITLE: American journal of obstetrics and gynecology
ISOABBREVIATION: Am. J. Obstet. Gynecol.
YEAR: 1992
MONTH: Jul
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0002-9378
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Am J Obstet Gynecol
COUNTRY: UNITED STATES
ISSNLINKING: 0002-9378
NLMUNIQUEID: 0370476
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
AA07535 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Australia
Female
Humans
Hysterectomy statistics & numerical data
Menstruation Disturbances surgery
Middle Aged surgery
Multivariate Analysis surgery
Pregnancy surgery
Questionnaires surgery
Twins, Dizygotic surgery
Twins, Monozygotic surgery
Uterine Diseases surgery
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's