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| PMID |
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| TITLE |
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| Variance components models for gene-environment interaction in quantitative trait locus linkage analysis. |
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| ABSTRACT |
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| Gene-environment interaction (G x E) is likely to be a common and important source of variation for complex behavioral traits. Gene-environment interaction, or genetic control of sensitivity to the environment, can be incorporated into variance components twin and sib-pair analyses by partitioning genetic effects into a mean part, which is independent of the environment, and a part that is a linear function of the environment. An approach described in a companion paper (Purcell, 2002) is applied to sib-pair variance components linkage analysis in two ways: allowing for quantitative trait locus by environment interaction and utilizing information on any residual interactions detected prior to analysis. As well as elucidating environmental pathways, consideration of G x E in quantitative and molecular studies will potentially direct and enhance gene-mapping efforts. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2003/02/08 04:00 |
| medline |
2003/04/05 05:00 |
| entrez |
2003/02/08 04:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Purcell S |
|
Purcell |
Shaun |
S |
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Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK. s.purcell@iop.kcl.ac.uk |
| Sham P |
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Sham |
Pak |
P |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 5 |
| ISSUE: 6 |
| TITLE: Twin research : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res |
| YEAR: 2002 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1369-0523 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res |
| COUNTRY: Australia |
| ISSNLINKING: 1369-0523 |
| NLMUNIQUEID: 9815819 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| EY-12562 |
NEI NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Computer Simulation |
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| Environment |
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| Genetic Linkage |
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| Genetics, Behavioral |
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| Humans |
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| Models, Genetic |
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| Quantitative Trait Loci |
genetics |
| Twins |
genetics |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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