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PMID |
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TITLE |
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Variance components models for gene-environment interaction in quantitative trait locus linkage analysis. |
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ABSTRACT |
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Gene-environment interaction (G x E) is likely to be a common and important source of variation for complex behavioral traits. Gene-environment interaction, or genetic control of sensitivity to the environment, can be incorporated into variance components twin and sib-pair analyses by partitioning genetic effects into a mean part, which is independent of the environment, and a part that is a linear function of the environment. An approach described in a companion paper (Purcell, 2002) is applied to sib-pair variance components linkage analysis in two ways: allowing for quantitative trait locus by environment interaction and utilizing information on any residual interactions detected prior to analysis. As well as elucidating environmental pathways, consideration of G x E in quantitative and molecular studies will potentially direct and enhance gene-mapping efforts. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
pubmed |
2003/02/08 04:00 |
medline |
2003/04/05 05:00 |
entrez |
2003/02/08 04:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Purcell S |
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Purcell |
Shaun |
S |
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Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College, London, UK. s.purcell@iop.kcl.ac.uk |
Sham P |
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Sham |
Pak |
P |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 5 |
ISSUE: 6 |
TITLE: Twin research : the official journal of the International Society for Twin Studies |
ISOABBREVIATION: Twin Res |
YEAR: 2002 |
MONTH: Dec |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 1369-0523 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Twin Res |
COUNTRY: Australia |
ISSNLINKING: 1369-0523 |
NLMUNIQUEID: 9815819 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, Non-U.S. Gov't |
Research Support, U.S. Gov't, P.H.S. |
Twin Study |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
EY-12562 |
NEI NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Computer Simulation |
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Environment |
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Genetic Linkage |
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Genetics, Behavioral |
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Humans |
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Models, Genetic |
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Quantitative Trait Loci |
genetics |
Twins |
genetics |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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