|
|
| PMID |
|
|
| TITLE |
|
| Escalation of drug use in early-onset cannabis users vs co-twin controls. |
|
| ABSTRACT |
|
| CONTEXT |
NlmCategory: BACKGROUND |
| Previous studies have reported that early initiation of cannabis (marijuana) use is a significant risk factor for other drug use and drug-related problems. |
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| To examine whether the association between early cannabis use and subsequent progression to use of other drugs and drug abuse/dependence persists after controlling for genetic and shared environmental influences. |
| DESIGN |
NlmCategory: METHODS |
| Cross-sectional survey conducted in 1996-2000 among an Australian national volunteer sample of 311 young adult (median age, 30 years) monozygotic and dizygotic same-sex twin pairs discordant for early cannabis use (before age 17 years). |
| MAIN OUTCOME MEASURES |
NlmCategory: METHODS |
| Self-reported subsequent nonmedical use of prescription sedatives, hallucinogens, cocaine/other stimulants, and opioids; abuse or dependence on these drugs (including cannabis abuse/dependence); and alcohol dependence. |
| RESULTS |
NlmCategory: RESULTS |
| Individuals who used cannabis by age 17 years had odds of other drug use, alcohol dependence, and drug abuse/dependence that were 2.1 to 5.2 times higher than those of their co-twin, who did not use cannabis before age 17 years. Controlling for known risk factors (early-onset alcohol or tobacco use, parental conflict/separation, childhood sexual abuse, conduct disorder, major depression, and social anxiety) had only negligible effects on these results. These associations did not differ significantly between monozygotic and dizygotic twins. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Associations between early cannabis use and later drug use and abuse/dependence cannot solely be explained by common predisposing genetic or shared environmental factors. The association may arise from the effects of the peer and social context within which cannabis is used and obtained. In particular, early access to and use of cannabis may reduce perceived barriers against the use of other illegal drugs and provide access to these drugs. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2003/01/22 04:00 |
| medline |
2003/02/01 04:00 |
| entrez |
2003/01/22 04:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Queensland Institute of Medical Research, Brisbane, Queensland, Australia. mlynskey@matlock.wustl.edu |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
|
| Slutske WS |
|
Slutske |
Wendy S |
WS |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
|
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 289 |
| ISSUE: 4 |
| TITLE: JAMA |
| ISOABBREVIATION: JAMA |
| YEAR: |
| MONTH: |
| DAY: |
| MEDLINEDATE: 2003 Jan 22-29 |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0098-7484 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: JAMA |
| COUNTRY: United States |
| ISSNLINKING: 0098-7484 |
| NLMUNIQUEID: 7501160 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| CommentIn |
JAMA. 2003 Jul 16;290(3):329; author reply 330-1 |
12865366 |
|
| CommentIn |
JAMA. 2003 Jul 16;290(3):329; author reply 330-1 |
12865368 |
|
| CommentIn |
JAMA. 2003 Jan 22-29;289(4):482-3 |
12533129 |
|
| CommentIn |
JAMA. 2003 Jul 16;290(3):329-30; author reply 330-1 |
12865367 |
|
| CommentIn |
JAMA. 2003 Jul 16;290(3):330; author reply 330-2 |
12865369 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA 12640 |
NIAAA NIH HHS |
United States |
| AA00277 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA09022 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| DA 14363 |
NIDA NIH HHS |
United States |
| DA 14632 |
NIDA NIH HHS |
United States |
| DA00272 |
NIDA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Age of Onset |
|
| Cross-Sectional Studies |
|
| Female |
|
| Humans |
|
| Logistic Models |
|
| Male |
|
| Marijuana Abuse |
physiopathology |
| Mental Disorders |
physiopathology |
| Risk Factors |
physiopathology |
| Socioeconomic Factors |
physiopathology |
| Substance-Related Disorders |
epidemiology |
| Twins, Dizygotic |
epidemiology |
| Twins, Monozygotic |
epidemiology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
