Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
12427781
TITLE
Protective role of appendicectomy on onset and severity of ulcerative colitis and Crohn's disease.
ABSTRACT
BACKGROUND AND AIMS NlmCategory: OBJECTIVE
Recent studies on appendicectomy rates in ulcerative colitis and Crohn's disease have generally not addressed the effect of appendicectomy on disease characteristics. The aims of this study were to compare appendicectomy rates in Australian inflammatory bowel disease patients and matched controls, and to evaluate the effect of prior appendicectomy on disease characteristics.
METHODS NlmCategory: METHODS
Patients were ascertained from the Brisbane Inflammatory Bowel Disease database. Controls matched for age and sex were randomly selected from the Australian Twin Registry. Disease characteristics included age at diagnosis, disease site, need for immunosuppression, and intestinal resection.
RESULTS NlmCategory: RESULTS
The study confirmed the significant negative association between appendicectomy and ulcerative colitis (odds ratio (OR) 0.23, 95% confidence interval (CI) 0.14-0.38; p<0.0001) and found a similar result for Crohn's disease once the bias of appendicectomy at diagnosis was addressed (OR 0.34, 95% CI 0.23-0.51; p<0.0001). Prior appendicectomy delayed age of presentation for both diseases and was statistically significant for Crohn's disease (p=0.02). In ulcerative colitis, patients with prior appendicectomy had clinically milder disease with reduced requirement for immunosuppression (OR 0.15, 95% CI 0.02-1.15; p=0.04) and proctocolectomy (p=0.02).
CONCLUSIONS NlmCategory: CONCLUSIONS
Compared with patients without prior appendicectomy, appendicectomy before diagnosis delays disease onset in ulcerative colitis and Crohn's disease and gives rise to a milder disease phenotype in ulcerative colitis.
DATE PUBLISHED
2002 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2002/11/13 04:00
medline 2002/12/18 04:00
entrez 2002/11/13 04:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Radford-Smith GL Radford-Smith G L GL Department of Gastroenterology, Royal Brisbane Hospital, Brisbane, Australia 4029. Graham_Radford-Smith@health.qld.gov.au
Edwards JE Edwards J E JE
Purdie DM Purdie D M DM
Pandeya N Pandeya N N
Watson M Watson M M
Martin NG Martin N G NG
Green A Green A A
Newman B Newman B B
Florin TH Florin T H J TH
INVESTIGATORS
JOURNAL
VOLUME: 51
ISSUE: 6
TITLE: Gut
ISOABBREVIATION: Gut
YEAR: 2002
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0017-5749
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Gut
COUNTRY: England
ISSNLINKING: 0017-5749
NLMUNIQUEID: 2985108R
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age of Onset
Appendectomy
Appendix pathology
Case-Control Studies pathology
Colectomy pathology
Colitis, Ulcerative therapy
Crohn Disease therapy
Female therapy
Humans therapy
Immunosuppressive Agents therapeutic use
Male therapeutic use
Odds Ratio therapeutic use
Smoking adverse effects
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Immunosuppressive Agents
OTHER ID's
OTHERID SOURCE
PMC1773455 NLM
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