Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
12372440
TITLE
The International Endogene Study: a collection of families for genetic research in endometriosis.
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
The aim of the International Endogene Study is to discover genes that influence susceptibility to endometriosis.
DESIGN NlmCategory: METHODS
The study brings together two research groups based in Australia and the United Kingdom that independently have been collecting families for linkage analysis and candidate gene studies. Both groups used similar methods to recruit families, obtain clinical notes, assign disease status based on the operative records and available histology, and collect common clinical data including age at onset of symptoms, age at diagnosis, and symptoms experienced.
SETTING NlmCategory: METHODS
Recruitment has been mainly from Australia, the United Kingdom, and the United States.
PATIENT(S) NlmCategory: METHODS
All affected participants have surgically confirmed disease.
INTERVENTION(S) NlmCategory: METHODS
None.
MAIN OUTCOME MEASURE(S) NlmCategory: METHODS
Clinical and epidemiological data.
RESULT(S) NlmCategory: RESULTS
To date, >1,100 families with affected sisters have been recruited, and >1,200 triads (affected women and both parents), for case-control studies.
CONCLUSION(S) NlmCategory: CONCLUSIONS
We have created the largest resource yet assembled of clinical data and DNA for linkage and association studies in endometriosis. The increase in power to detect susceptibility genes vindicates the decision to merge the two studies and demonstrates the value of large-scale international collaboration.
DATE PUBLISHED
2002 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2002/10/10 04:00
medline 2002/11/26 04:00
entrez 2002/10/10 04:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Treloar S Treloar Susan S Cooperative Research Centre for Discovery of Genes for Common Human Diseases, Queensland Institute of Medical Research, Brisbane, Australia. suet@qimr.edu.au
Hadfield R Hadfield Ruth R
Montgomery G Montgomery Grant G
Lambert A Lambert Ann A
Wicks J Wicks Jacki J
Barlow DH Barlow David H DH
O'Connor DT O'Connor Daniel T DT
Kennedy S Kennedy Stephen S
International Endogene Study Group
INVESTIGATORS
JOURNAL
VOLUME: 78
ISSUE: 4
TITLE: Fertility and sterility
ISOABBREVIATION: Fertil. Steril.
YEAR: 2002
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0015-0282
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Fertil Steril
COUNTRY: United States
ISSNLINKING: 0015-0282
NLMUNIQUEID: 0372772
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Australia
DNA analysis
Dysmenorrhea analysis
Endometriosis pathology
Female pathology
Genetic Linkage pathology
Genetic Predisposition to Disease pathology
Great Britain pathology
Humans pathology
Infertility, Female etiology
International Cooperation etiology
Pelvic Pain etiology
United States etiology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
9007-49-2 DNA
OTHER ID's