Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
About GenEpi
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
11901127
TITLE
Linkage disequilibrium in domestic sheep.
ABSTRACT
The last decade has seen a dramatic increase in the number of livestock QTL mapping studies. The next challenge awaiting livestock geneticists is to determine the actual genes responsible for variation of economically important traits. With the advent of high density single nucleotide polymorphism (SNP) maps, it may be possible to fine map genes by exploiting linkage disequilibrium between genes of interest and adjacent markers. However, the extent of linkage disequilibrium (LD) is generally unknown for livestock populations. In this article microsatellite genotype data are used to assess the extent of LD in two populations of domestic sheep. High levels of LD were found to extend for tens of centimorgans and declined as a function of marker distance. However, LD was also frequently observed between unlinked markers. The prospects for LD mapping in livestock appear encouraging provided that type I error can be minimized. Properties of the multiallelic LD coefficient D' were also explored. D' was found to be significantly related to marker heterozygosity, although the relationship did not appear to unduly influence the overall conclusions. Of potentially greater concern was the observation that D' may be skewed when rare alleles are present. It is recommended that the statistical significance of LD is used in conjunction with coefficients such as D' to determine the true extent of LD.
DATE PUBLISHED
2002 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2002/03/20 10:00
medline 2002/09/07 10:01
entrez 2002/03/20 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
McRae AF McRae A F AF AgResearch, Invermay Agricultural Centre, Mosgiel, New Zealand.
McEwan JC McEwan J C JC
Dodds KG Dodds K G KG
Wilson T Wilson T T
Crawford AM Crawford A M AM
Slate J Slate J J
INVESTIGATORS
JOURNAL
VOLUME: 160
ISSUE: 3
TITLE: Genetics
ISOABBREVIATION: Genetics
YEAR: 2002
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0016-6731
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Genetics
COUNTRY: United States
ISSNLINKING: 0016-6731
NLMUNIQUEID: 0374636
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Vet Immunol Immunopathol. 1999 Dec 15;72(1-2):219-29 10614512
Cites Am J Hum Genet. 2001 Jan;68(1):191-197 11083947
Cites Science. 2000 May 19;288(5469):1248-51 10818001
Cites Bioinformatics. 2000 Feb;16(2):182-3 10842743
Cites Nat Genet. 2000 Jul;25(3):279-83 10888873
Cites Nat Genet. 2000 Jul;25(3):320-3 10888882
Cites Nat Genet. 2000 Jul;25(3):324-8 10888883
Cites Am J Hum Genet. 2000 Oct;67(4):926-35 10961910
Cites Genome Res. 2000 Oct;10(10):1435-44 11042143
Cites Am J Hum Genet. 2000 Dec;67(6):1544-54 11078480
Cites Evolution. 2000 Oct;54(5):1809-12 11108607
Cites Philos Trans R Soc Lond B Biol Sci. 2000 Nov 29;355(1403):1573-80 11127902
Cites Nature. 2001 Feb 15;409(6822):928-33 11237013
Cites Biol Reprod. 2001 Apr;64(4):1225-35 11259271
Cites Nature. 2001 May 10;411(6834):199-204 11346797
Cites Genome Res. 2001 Jul;11(7):1275-89 11435411
Cites Genetics. 1987 Oct;117(2):331-41 3666445
Cites Genetics. 1988 Nov;120(3):849-52 3224810
Cites Nat Genet. 1993 Aug;4(4):410-4 8401591
Cites Science. 1994 Mar 25;263(5154):1771-4 8134840
Cites Genetics. 1994 May;137(1):331-6 8056320
Cites Genetics. 1995 Feb;139(2):907-20 7713441
Cites Genome Res. 1997 Sep;7(9):910-6 9314496
Cites Mamm Genome. 1998 Mar;9(3):204-9 9501303
Cites Curr Opin Biotechnol. 1998 Dec;9(6):578-94 9889136
Cites Nat Genet. 1999 Jun;22(2):139-44 10369254
Cites Genome Res. 2000 Feb;10(2):220-7 10673279
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Animals
Genetic Markers
Haplotypes
Heterozygote
Linkage Disequilibrium
Microsatellite Repeats
Models, Genetic
Quantitative Trait, Heritable
Sheep genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Genetic Markers
OTHER ID's
OTHERID SOURCE
PMC1462013 NLM