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| PMID |
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| TITLE |
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| Personality and the genetic risk for alcohol dependence. |
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| ABSTRACT |
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| The extent to which the genetic risk for alcohol dependence (AD) and conduct disorder (CD) and their common genetic risk overlap with genetic factors contributing to variation in dimensions of personality was examined in a study of 6,453 individuals from 3,383 adult male and female same-sex and unlike-sex twin pairs from the Australian Twin Registry. The associations between the personality dimensions of positive emotionality, negative emotionality, and AD and CD risk were modest, whereas the associations between behavioral undercontrol and AD and CD risk were substantially higher. Genetic influences contributing to variation in behavioral undercontrol accounted for about 40% of the genetic variation in AD and CD risk and about 90% of the common genetic risk for AD and CD. These results suggest that genetic factors contributing to variation in dimensions of personality, particularly behavioral undercontrol, account for a substantial proportion of the genetic diathesis for AD and most of the common genetic diathesis for AD and CD among both men and women. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2002/03/02 10:00 |
| medline |
2002/05/22 10:01 |
| entrez |
2002/03/02 10:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Slutske WS |
|
Slutske |
Wendy S |
WS |
|
Department of Psychological Sciences and Missouri Alcoholism Research Center, University of Missouri--Columbia, 65211, USA. SlutskeW@missouri.edu |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
|
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
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| INVESTIGATORS |
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| JOURNAL |
|
| VOLUME: 111 |
| ISSUE: 1 |
| TITLE: Journal of abnormal psychology |
| ISOABBREVIATION: J Abnorm Psychol |
| YEAR: 2002 |
| MONTH: Feb |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0021-843X |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Abnorm Psychol |
| COUNTRY: United States |
| ISSNLINKING: 0021-843X |
| NLMUNIQUEID: 0034461 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
|
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA00264 |
NIAAA NIH HHS |
United States |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| DA07261 |
NIDA NIH HHS |
United States |
| MH17104 |
NIMH NIH HHS |
United States |
|
| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
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| Aged |
|
| Aged, 80 and over |
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| Alcoholism |
genetics |
| Female |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Middle Aged |
genetics |
| Personality Disorders |
psychology |
| Personality Inventory |
psychology |
| Risk Factors |
psychology |
| Twins |
psychology |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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