|
|
| PMID |
|
|
| TITLE |
|
| Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| This paper examines genetic and environmental contributions to risk of cannabis dependence. |
| METHOD |
NlmCategory: METHODS |
| Symptoms of cannabis dependence and measures of social, family and individual risk factors were assessed in a sample of 6265 young adult male and female Australian twins born 1964-1971. |
| RESULTS |
NlmCategory: RESULTS |
| Symptoms of cannabis dependence were common: 11.0% of sample (15.1% of men and 7.8% of women) reported two or more symptoms of dependence. Correlates of cannabis dependence included educational attainment, exposure to parental conflict, sexual abuse, major depression, social anxiety and childhood conduct disorder. However, even after control for the effects of these factors, there was evidence of significant genetic effects on risk of cannabis dependence. Standard genetic modelling indicated that 44.7% (95% CI = 15-72.2) of the variance in liability to cannabis dependence could be accounted for by genetic factors, 20.1% (95% CI = 0-43.6) could be attributed to shared environment factors and 35.3% (95% CI = 26.4-45.7) could be attributed to non-shared environmental factors. However, while there was no evidence of significant gender differences in the magnitude of genetic and environmental influences, a model which assumed both genetic and shared environmental influences on risks of cannabis dependence among men and shared environmental but no genetic influences among women provided an equally good fit to the data. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| There was consistent evidence that genetic risk factors are important determinants of risk of cannabis dependence among men. However, it remains uncertain whether there are genetic influences on liability to cannabis dependence among women. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2002/03/02 10:00 |
| medline |
2002/08/29 10:01 |
| entrez |
2002/03/02 10:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Lynskey MT |
|
Lynskey |
M T |
MT |
|
National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia. |
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Nelson EC |
|
Nelson |
E C |
EC |
|
|
| Bucholz KK |
|
Bucholz |
K K |
KK |
|
|
| Madden PA |
|
Madden |
P A F |
PA |
|
|
| Slutske WS |
|
Slutske |
W S |
WS |
|
|
| Statham DJ |
|
Statham |
D J |
DJ |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 32 |
| ISSUE: 2 |
| TITLE: Psychological medicine |
| ISOABBREVIATION: Psychol Med |
| YEAR: 2002 |
| MONTH: Feb |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0033-2917 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Psychol Med |
| COUNTRY: England |
| ISSNLINKING: 0033-2917 |
| NLMUNIQUEID: 1254142 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA00277 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA09022 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA10333 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| DA00272 |
NIDA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Australia |
|
| Diseases in Twins |
|
| Female |
|
| Genetic Predisposition to Disease |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Marijuana Abuse |
psychology |
| Risk |
psychology |
| Sex Factors |
psychology |
| Social Environment |
psychology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
