Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11838537
TITLE
Genetic influence on ERP slow wave measures of working memory.
ABSTRACT
Individual differences in the variance of event-related potential (ERP) slow wave (SW) measures were examined. SW was recorded at prefrontal and parietal sites during memory and sensory trials of a delayed-response task in 391 adolescent twin pairs. Familial resemblance was identified and there was a strong suggestion of genetic influence. A common genetic factor influencing memory and sensory SW was identified at the prefrontal site (accounting for an estimated 35%-37% of the reliable variance) and at the parietal site (51%-52% of the reliable variance). Remaining reliable variance was influenced by unique environmental factors. Measurement error accounted for 24% to 30% of the total variance of each variable. The results show genetic independence for recording site, but not trial type, and suggest that the genetic factors identified relate more directly to brain structures, as defined by the cognitive functions they support, than to the cognitive networks that link them.
DATE PUBLISHED
2001 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2002/02/13 10:00
medline 2002/04/17 10:01
entrez 2002/02/13 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hansell NK Hansell N K NK Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Royal Brisbane Hospital, Australia. narelleH@qimr.edu.au
Wright MJ Wright M J MJ
Geffen GM Geffen G M GM
Geffen LB Geffen L B LB
Smith GA Smith G A GA
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 31
ISSUE: 6
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2001
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Cerebral Cortex physiology
Electroencephalography physiology
Female physiology
Genetic Variation physiology
Humans physiology
Individuality physiology
Intelligence genetics
Male genetics
Models, Genetic genetics
Parietal Lobe physiology
Prefrontal Cortex physiology
Retention (Psychology) physiology
Social Environment physiology
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's