Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
11838533
TITLE
Genetic influence on the variance in P3 amplitude and latency.
ABSTRACT
The P3(00) event-related potential (ERP) component is widely used as a measure of cognitive functioning and provides a sensitive electrophysiological index of the attentional and working memory demands of a task. This study investigated what proportion of the variance in the amplitude and latency of the P3, elicited in a delayed response working memory task, could be attributed to genetic factors. In 335 adolescent twin pairs and 48 siblings, the amplitude and latency of the P3 were examined at frontal, central, and parietal sites. Additive genetic factors accounted for 48% to 61% of the variance in P3 amplitude. Approximately one-third of the genetic variation at frontal sites was mediated by a common genetic factor that also influenced the genetic variation at parietal and central sites. Familial resemblance in P3 latency was due to genetic influence that accounted for 44% to 50% of the variance. Genetic covariance in P3 latency across sites was substantial, with a large part of the variance found at parietal, central, and frontal sites attributed to a common genetic factor. The findings provide further evidence that the P3 is a promising phenotype of neural activity of the brain and has the potential to be used in linkage and association analysis in the search for quantitative trait loci (QTLs) influencing cognition.
DATE PUBLISHED
2001 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
pubmed 2002/02/13 10:00
medline 2002/04/17 10:01
entrez 2002/02/13 10:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wright MJ Wright M J MJ Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Royal Brisbane Hospital, Australia. margieW@qimr.edu.au
Hansell NK Hansell N K NK
Geffen GM Geffen G M GM
Geffen LB Geffen L B LB
Smith GA Smith G A GA
Martin NG Martin N G NG
INVESTIGATORS
JOURNAL
VOLUME: 31
ISSUE: 6
TITLE: Behavior genetics
ISOABBREVIATION: Behav. Genet.
YEAR: 2001
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 0001-8244
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Attention physiology
Cerebral Cortex physiology
Electroencephalography physiology
Event-Related Potentials, P300 genetics
Female genetics
Genetic Variation genetics
Humans genetics
Intelligence genetics
Male genetics
Mental Recall physiology
Parietal Lobe physiology
Reaction Time genetics
Twins genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's