|
|
| PMID |
|
|
| TITLE |
|
| Genetic covariation of neuroticism with monoamine oxidase activity and smoking. |
|
| ABSTRACT |
|
|
|
| Variation in the personality trait of neuroticism is known to be affected by genetic influences, but despite a number of association studies, the genes involved have not yet been characterized. In a recent study of platelet monoamine oxidase in 1,551 twin subjects, we found a significant association between monoamine oxidase activity and scores on the Eysenck Personality Questionnaire neuroticism scale. Further analyses presented here indicate that both neuroticism and monoamine oxidase activity are associated with variation in smoking habits, and that adjusting for the effect of smoking strengthens the association between MAO and neuroticism. Analysis of the genetic and environmental sources of covariation between neuroticism, smoking, and monoamine oxidase activity show that approximately 8% of the genetic variance in neuroticism is due to the same additive genetic effects that contribute to variation in monoamine oxidase activity, suggesting that variation in neuroticism is associated in part with aspects of serotonin metabolism. |
| Copyright 2001 Wiley-Liss, Inc. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2002/01/23 10:00 |
| medline |
2002/03/07 10:01 |
| entrez |
2002/01/23 10:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kirk KM |
|
Kirk |
K M |
KM |
|
Department of Psychiatry, University of Queensland, Brisbane, Australia. kathe@qimr.edu.au |
| Whitfield JB |
|
Whitfield |
J B |
JB |
|
|
| Pang D |
|
Pang |
D |
D |
|
|
| Heath AC |
|
Heath |
A C |
AC |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 105 |
| ISSUE: 8 |
| TITLE: American journal of medical genetics |
| ISOABBREVIATION: Am. J. Med. Genet. |
| YEAR: 2001 |
| MONTH: Dec |
| DAY: 8 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0148-7299 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Am J Med Genet |
| COUNTRY: United States |
| ISSNLINKING: 0148-7299 |
| NLMUNIQUEID: 7708900 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Female |
|
| Genetic Variation |
|
| Humans |
|
| Male |
|
| Models, Biological |
|
| Monoamine Oxidase |
metabolism |
| Multivariate Analysis |
metabolism |
| Neurotic Disorders |
psychology |
| Personality Inventory |
statistics & numerical data |
| Phenotype |
statistics & numerical data |
| Smoking |
statistics & numerical data |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| EC 1.4.3.4 |
Monoamine Oxidase |
|
| OTHER ID's |
|
|
|
