|
|
| PMID |
|
|
| TITLE |
|
| Phenotypic and genetic analyses of a short measure of psychosis-proneness in a large-scale Australian twin study. |
|
| ABSTRACT |
|
|
|
| Previous genetic analyses of psychosis proneness have been limited by their small sample size. For the purposes of large-scale screening, a 12-item questionnaire was developed through a two-stage process of reduction from the full Chapman and Chapman scales. 3685 individuals (including 1438 complete twin pairs) aged 18-25 years and enrolled in the volunteer Australian Twin Registry returned a mail questionnaire which included this psychosis proneness scale and the Eysenck Personality Questionnaire. Despite the brevity of the questionnaire, item and factor analysis identified four unambiguous and essentially uncorrelated scales. There were (1) Perceptual Aberration--Magical Ideation; (2) Hypomania--Impulsivity/Nonconformity; (3) Social Anhedonia and (4) Physical Anhedonia. Model-fitting analyses showed additive genetic and specific environmental factors were sufficient for three of the four scales, with the Social Anhedonia scale requiring also a parameter for genetic dominance. There was no evidence for the previously hypothesised sex differences in the genetic determination of psychosis-proneness. The potential value of multivariate genetic analysis to examine the relationship between these four scales and dimensions of personality is discussed. The growing body of longitudinal evidence on psychosis-proneness suggests the value of incorporating this brief measure into developmental twin studies. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2001/10/23 10:00 |
| medline |
2002/01/05 10:01 |
| entrez |
2001/10/23 10:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hay DA |
|
Hay |
D A |
DA |
|
School of Psychology, Curtin University of Technology and Mental Health Research Institute of Victoria, Australia. D.Hay@psychology.curtin.edu.au |
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Foley D |
|
Foley |
D |
D |
|
|
| Treloar SA |
|
Treloar |
S A |
SA |
|
|
| Kirk KM |
|
Kirk |
K M |
KM |
|
|
| Heath AC |
|
Heath |
A C |
AC |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 4 |
| ISSUE: 1 |
| TITLE: Twin research : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res |
| YEAR: 2001 |
| MONTH: Feb |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1369-0523 |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Twin Res |
| COUNTRY: Australia |
| ISSNLINKING: 1369-0523 |
| NLMUNIQUEID: 9815819 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Research Support, U.S. Gov't, P.H.S. |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Australia |
|
| Factor Analysis, Statistical |
|
| Female |
|
| Humans |
|
| Male |
|
| Phenotype |
|
| Psychological Tests |
|
| Psychotic Disorders |
genetics |
| Questionnaires |
genetics |
| Registries |
genetics |
| Reproducibility of Results |
genetics |
| Sample Size |
genetics |
| Twin Studies as Topic |
genetics |
| Twins, Dizygotic |
genetics |
| Twins, Monozygotic |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
