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| PMID |
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| TITLE |
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| Human twinning is not linked to the region of chromosome 4 syntenic with the sheep twinning gene FecB. |
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| ABSTRACT |
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| The tendency to dizygotic (DZ) twinning is inherited in both humans and sheep, and a fecundity gene in sheep (FecB) maps to sheep chromosome 6, syntenic with human 4q21-25. Our aim was to see whether a gene predisposing to human DZ twinning mapped to this region. DNA was collected from 169 pairs and 17 sets of 3 sisters (trios) from Australia and New Zealand who had each had spontaneous DZ twins, mostly before the age of 35, and from a replication sample of 111 families (92 affected sister pairs) from The Netherlands. Exclusion mapping was carried out after typing 26 markers on chromosome 4, of which 8 spanned the region likely to contain the human homologue of the sheep FecB gene. We used nonparametric affected sib pair methods for linkage analysis [ASPEX 2.2, Hinds and Risch, 1999]. Complete exclusion of linkage (lod < -2) of a gene conferring a relative risk for sibs as low as 1.5 (lambda(s) > 1.5) was obtained for all but the p terminus region on chromosome 4. Exclusion in the syntenic region was stronger, down to lambda(s) = 1.3. We concluded that if there is a gene influencing DZ twinning on chromosome 4, its effect must be minor. |
| Copyright 2001 Wiley-Liss, Inc. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| pubmed |
2001/05/09 10:00 |
| medline |
2001/09/14 10:01 |
| entrez |
2001/05/09 10:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Duffy DL |
|
Duffy |
D L |
DL |
|
Genetic Epidemiology Unit, Queensland Institute of Medical Research and Joint Genetics Program, The University of Queensland, Brisbane, Queensland, Australia. davidD@qimr.edu.au |
| Montgomery GW |
|
Montgomery |
G W |
GW |
|
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| Hall J |
|
Hall |
J |
J |
|
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| Mayne C |
|
Mayne |
C |
C |
|
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| Healey SC |
|
Healey |
S C |
SC |
|
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| Brown J |
|
Brown |
J |
J |
|
|
| Boomsma DI |
|
Boomsma |
D I |
DI |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 100 |
| ISSUE: 3 |
| TITLE: American journal of medical genetics |
| ISOABBREVIATION: Am. J. Med. Genet. |
| YEAR: 2001 |
| MONTH: May |
| DAY: 1 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0148-7299 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Am J Med Genet |
| COUNTRY: United States |
| ISSNLINKING: 0148-7299 |
| NLMUNIQUEID: 7708900 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
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| Animals |
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| Chromosome Mapping |
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| Chromosomes, Human, Pair 4 |
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| DNA |
genetics |
| Female |
genetics |
| Genetic Linkage |
genetics |
| Genetic Markers |
genetics |
| Genome |
genetics |
| Humans |
genetics |
| Sheep |
genetics |
| Species Specificity |
genetics |
| Twins, Dizygotic |
genetics |
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Genetic Markers |
| 9007-49-2 |
DNA |
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| OTHER ID's |
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